Evidence map›Paper›PMID 33489454›Full record

ArticleAmerican journal of blood research2020

Al-hijamah (the triple S treatment of prophetic medicine) exerts cardioprotective, tissue-protective and immune potentiating effects in thalassemic children: a pilot clinical trial.

Mohamed El-Shanshory, Nahed Mohammed Hablas, Yasmin Shebel, Osama Alhadramy, Rehab El-Tahlawi, Moutasem Salih Aboonq, Tamer M Soliman, Abdelhady Ragab Abdel-Gawad, Sayed Mostafa El Sayed, Hesham I Abdallah and 13 more

Abstract read
In one paragraph

Article in American journal of blood research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Mohamed El-ShanshoryProphetic Medicine Course and Research Group, Taibah College of Medicine Al-Madinah Al-Munawwarah, Saudi Arabia.
Nahed Mohammed HablasDepartment of Pediatrics, Tanta University Faculty of Medicine Tanta, Gharbia, Egypt.
Yasmin ShebelDepartment of Pediatrics, Tanta University Faculty of Medicine Tanta, Gharbia, Egypt.
Osama AlhadramyDivision of Cardiology, Department of Medicine, Taibah College of Medicine, Taibah University Al-Madinah Al-Munawwarah, Saudi Arabia.
Rehab El-TahlawiDepartment of Microbiology, College of Medicine, Taibah University Saudi Arabia.
Moutasem Salih AboonqDepartment of Medical Physiology, Taibah College of Medicine, Taibah University Al-Madinah Al-Munawwarah, Saudi Arabia.
Tamer M SolimanDepartment of Clinical Pathology, Sohag Faculty of Medicine, Sohag University Sohag, Egypt.
Abdelhady Ragab Abdel-GawadDepartment of Clinical Pathology, Sohag Faculty of Medicine, Sohag University Sohag, Egypt.
Sayed Mostafa El SayedDepartment of Anatomy, Faculty of Medicine, Ain Shams University Egypt.
Hesham I AbdallahDepartment of Anatomy, Faculty of Medicine, Ain Shams University Egypt.
Hany Salah MahmoudCenter of Scientific Foundation for Experimental Studies and Research Ismailia, Egypt.
Hassan El-AllafDepartment of Medical Physiology, Sohag Faculty of Medicine, Sohag University Egypt.
Samer El-SawyDepartment of Medical Biochemistry, Sohag Faculty of Medicine, Sohag University Egypt.
Reda S YousefDepartment of Medical Biochemistry, Sohag Faculty of Medicine, Sohag University Egypt.
Mostafa Abu-El NagaDepartment of Anatomy, College of Medicine, Al-Rayyan National Colleges Al-Madinah, Saudi Arabia.
Reham A MariahDepartment of Medical Biochemistry, Tanta Faculty of Medicine, Tanta University Tanta, Egypt.
Manal Mohamed Helmy NaboDivision of Pediatric Cardiology, Pediatrics Department, Maternity and Children Hospital Hail, Saudi Arabia.
Mohamed Abdel-HaleemDepartment of Ear, Nose and Throat, Taibah Faculty of Medicine, Taibah University Al-Madinah Al-Munawwarah, Saudi Arabia.
Ahmed Alamir MahmoudDepartment of Medical Biochemistry, Sohag Faculty of Medicine, Sohag University Egypt.
Mohammad Ahmad HassanDepartment of Pediatrics, Sohag Faculty of Medicine Sohag, Egypt.
Areej Hesham Al ArabiDepartment of Cardiology, Governorate of Health, Uhud Hospital Al-Madinah Al-Munawwarah, Saudi Arabia.
Abdullah Ahmed AlnakhliDepartment of Cardiology, Governorate of Health, Uhud Hospital Al-Madinah Al-Munawwarah, Saudi Arabia.
Salah Mohamed El SayedProphetic Medicine Course and Research Group, Taibah College of Medicine Al-Madinah Al-Munawwarah, Saudi Arabia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Thalassemia is a major health problem in affected children due to iron overload, increased oxidative stress, atherogenic lipid profile and tissue-damage. This study aims at investigating the cardioprotective and tissue-protective benefits of Al-hijamah and their impact on cell-mediated immunity for treating thalassemic children. This study aimed also at investigating the tissue-clearance principle of Taibah mechanism: whenever pathological substances are to be cleared from the human body, Al-hijamah is indicated. Al-hijamah was done to thalassemic children (15 males and 5 females having a mean age of 9.07 ± 4.26 years) using sterile disposable sets in a complete aseptic hospital environment. Prior ethical committee agreement (in addition to written patient's consents) was obtained from Tanta Faculty of Medicine, Egypt. Twenty thalassemic children received iron chelation therapy plus Al-hijamah for one session (30-60 minutes) versus an age and sex-matched thalassemic control group treated with iron chelation therapy only. Al-hijamah is a quite safe outpatient hematological procedure that significantly decreased serum cholesterol (from 129.75 ± 3.67 to 103.5 ± 4.18 mg/dl) and decreased serum triglycerides (from 109.25 ± 8.96 to 91.95 ± 7.22 mg/dl). Interestingly, Al-hijamah exerted significant tissue-protective effects (it decreased serum GPT from 98.65 ± 12.27 to 71.65 ± 32.78 U/L and serum GOT from 96.35 ± 14.33 to 69.35 ± 34.37 U/L). Al-hijamah-induced ferritin excretion caused decreased serum ferritin (high serum ferritin negatively correlated with cell mediated immunity). Al-hijamah exerted cardioprotective and tissue-protective and hypolipidemic effects. Al-hijamah decreased serum cholesterol and is cardioprotective for thalassemic patients as it protects against atherogenesis and atherosclerosis. Medical practice of Al-hijamah is strongly recommended in hospitals. Al-hijamah cleared blood significantly from causative pathological substances e.g. serum ferritin resulting in enhanced cell-mediated immunity (in agreement with the evidence-based Taibah mechanism).

Indexed as

Al-hijamahAl-hijamah indicescholesterolclearanceiron chelation therapyliver functionsThalassemia

Identifiers

PMID33489454
PMCPMC7811902

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.