Evidence map›Paper›PMID 33489447›Full record

ReviewAmerican journal of blood research2020

Cancer immunotherapy: a promising dawn in cancer research.

Banashree Bondhopadhyay, Sandeep Sisodiya, Atul Chikara, Asiya Khan, Pranay Tanwar, Dil Afroze, Neha Singh, Usha Agrawal, Ravi Mehrotra, Showket Hussain

Open access · greenAbstract readReview
In one paragraph

Review in American journal of blood research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 2 pooled it
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 2 syntheses or guidelines pooled it, 41 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. Review
  6. Observational
  7. Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Review
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Banashree BondhopadhyayDivision of Molecular Oncology and Cellular & Molecular Diagnostics, National Institute of Cancer Prevention and Research (NICPR) Noida, India.
Sandeep SisodiyaDivision of Molecular Oncology and Cellular & Molecular Diagnostics, National Institute of Cancer Prevention and Research (NICPR) Noida, India.
Atul ChikaraDivision of Molecular Oncology and Cellular & Molecular Diagnostics, National Institute of Cancer Prevention and Research (NICPR) Noida, India.
Asiya KhanAll India Institute of Medical Science (AIIMS) New Delhi, India.
Pranay TanwarAll India Institute of Medical Science (AIIMS) New Delhi, India.
Dil AfrozeSher-i-Kashmir Institute of Medical Sciences Soura (SKIMS) Srinagar, Jammu and Kashmir, India.
Neha SinghDepartment of Surgical and Perioperative Sciences, Umea University Sweden.
Usha AgrawalNational Institute of Pathology New Delhi, India.
Ravi MehrotraDivision of Molecular Oncology and Cellular & Molecular Diagnostics, National Institute of Cancer Prevention and Research (NICPR) Noida, India.
Showket HussainDivision of Molecular Oncology and Cellular & Molecular Diagnostics, National Institute of Cancer Prevention and Research (NICPR) Noida, India.
Umeå University · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cancer is a highly proliferative disease, which is caused due to the loss of regulation of cell cycle and apoptosis, DNA damage, faulty repair system etc. The cancer microenvironment plays a pivotal role in disease progression as they contain different types of innate and adaptive immune cells. The most important molecules that establish a correlation between inflammation, innate immunity, adaptive immunity, and cancer are the molecules released by inflammatory cells in cancer microenvironment. These molecules secreted by the immune cells, which might activate a pro-tumorigenic and anti-tumorigenic response in cancer. In inflammatory microenvironment, the equilibrium state of immunosuppressive and immunostimulatory signals are important in tumor suppression. The immunotherapeutic approaches could be more effective in cancer treatment. However, advancement in immunobiology and cancer are improving the prospects of immunotherapy alone and/or in combination with the conventional therapies. Thus, the review attempts to highlight a promising and futuristic immunotherapeutic approach in combination with conventional treatment modalities.

Indexed as

adaptive immunityCancerimmunotherapiesinnate immunityoncolytic viruses and bacteriatumor-immuno printing strategy

Identifiers

PMID33489447
PMCPMC7811907
OpenAlexW3123929348

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.