ReviewAmerican journal of blood research2020
Extramedullary manifestations in acute lymphoblastic leukemia in children: a systematic review and guideline-based approach of treatment.
Review in American journal of blood research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 31 citations in OpenAlex.
- Treatment of leukemic ocular infiltrations with intraarterial chemotherapy in very early mixed relapse of B-cell acute lymphoblastic leukemia.Haematologica · 2026Article
- Synthetic and conventional magnetic resonance imaging for knee assessment in children with leukemia: a comparative study.Quantitative imaging in medicine and surgery · 2026Article
- CRLF2 rearrangement and extramedullary disease in B-cell acute lymphoblastic leukemia: a possible link?Blood advances · 2026Article
- Liver involvement in pediatric acute leukemia: subtype differences and complex hepatic injury as a novel marker for AML risk stratification.Frontiers in oncology · 2026Article
- Ocular involvement in newly diagnosed pediatric leukemia: A systematic review and meta-analysis.Pediatric investigation · 2025Review
- Musculoskeletal manifestations caused by malignancies in children with various malignancies: a cross-sectional study in southeastern Iran.Annals of medicine and surgery (2012) · 2025Article
- Article
- A Unique Case of Extramedullary Relapse in Acute Lymphoblastic Leukemia: Testicular to Ocular, Cardiac, and Colonic Involvement and the Role of Sperm Phenotyping in Diagnosis-Case Report and Literature Review.Journal of clinical medicine · 2025Article
- Beyond the Marrow: Unveiling Uncommon Sites of ALL Relapse withWorld journal of nuclear medicine · 2024Article
- Unexpected Mediastinal Mass Etiology in B-Acute Lymphoblastic Leukemia.Journal of immunotherapy and precision oncology · 2024Article
- Article
- [Advancements in the diagnosis and treatment of pediatric acute liver failure].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2024Review
- Article
- Effect of oral silymarin on liver function in pediatric acute lymphoblastic leukemia in the maintenance phase: a double-blind randomized clinical trial.Frontiers in pharmacology · 2024Article
- Effects of oral Lcarnitine supplementation on liver enzymes in pediatric acute lymphoblastic leukemia patients in the maintenance phase of treatment: a randomized clinical trial study.Frontiers in pharmacology · 2024Article
- Pleural and pericardial effusion revealed underlying acute lymphoblastic leukemia: a case report.Annals of medicine and surgery (2012) · 2023Article
- Neurological Involvement in Pediatric Patients with Acute Leukemia: A Retrospective Cohort.Children (Basel, Switzerland) · 2022Article
- Characterization of extramedullary disease in B-ALL and response to CAR T-cell therapy.Blood advances · 2022Article
- Article
- Malignant hypercalcemia as the debut of acute lymphoblastic leukemia in a pediatric patient-a diagnostic and therapeutic approach: Case report.Frontiers in pediatrics · 2022Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveAcute lymphoblastic leukemia (ALL) may present with signs and symptoms related to extramedullary involvement, therefore, leads to delayed diagnosis of ALL in children. This study aims to consider the extramedullary manifestations of ALL in children and their proper treatment.
methodThe databases were searched for all relevant subjects including "acute lymphoblastic leukemia", "clinical presentation", "unusual presentation", "childhood acute lymphoblastic leukemia", "presenting features of ALL", "extramedullary presentation", and "atypical presentation" from April 1968 to June 2020. The Inclusion criteria for this review study were all cases reported, case series, and studies about extramedullary presentations of ALL in pediatrics. Eighty-seven studies had inclusion criteria. All reported studies were analyzed given their extramedullary presentations, age, sex, treatment option, and prognostic factors. A two-sided
resultIn this review study, the extramedullary initial signs and symptoms of ALL were related to musculoskeletal system 17 (19.5%) especially bony symptoms and hypercalcemia. The additional extramedullary presentations of ALL in order of frequency include; renal involvement, 17 (19.5%), hepatic symptom 12 (13.8%), orbital presentation 10 (11.5%), neurologic signs 8 (9%), dermatological manifestations 5 (5.8%), oral presentations 5 (5.8%), hypereosinophilia 5 (5.8%), abdominal manifestation 3 (3.5%), pericardial involvement 2 (2.3%), and the other miscellaneous presentations 3 (3.5%).
conclusionThe clinicians must become familiar with these extramedullary presentations of ALL in pediatrics to avoid the delayed diagnosis of this disease and increase the probable chance of survival by early detection.
Indexed as
Identifiers
33489446PMC7811904W3121194302What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.