ArticleRoyal Society open science2020
Numerical models for assessing the risk of leaflet thrombosis post-transcatheter aortic valve-in-valve implantation.
Article in Royal Society open science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 27 citations in OpenAlex.
- Understanding the mechanisms of TAVI durability through computational modelling: a multidisciplinary review.European heart journal. Digital health · 2026Review
- Evolving capabilities of computed tomography imaging for transcatheter valvular heart interventions - new opportunities for precision medicine.The international journal of cardiovascular imaging · 2026Review
- Advanced Computer Simulation Based on Cardiac Imaging in Planning of Structural Heart Disease Interventions.Journal of clinical medicine · 2025Review
- A novel computational method to predict hypoattenuated leaflet thickening post-transcatheter aortic valve replacement using preprocedural computed tomography scans.JTCVS structural and endovascular · 2025Article
- Case Report: Patient-specific three-dimensional printing and computational fluid dynamics in the planning of transcatheter aortic valve replacement for quadricuspid aortic valve.Frontiers in cardiovascular medicine · 2025Article
- Sensitivity of Post-TAVR Hemodynamics to the Distal Aortic Arch Anatomy: A High-Fidelity CFD Study.Cardiovascular engineering and technology · 2024Article
- A Fibrin-Thrombin Based In Vitro Perfusion System to Study Flow-Related Prosthetic Heart Valves Thrombosis.Annals of biomedical engineering · 2024Article
- Analysis of fibrocalcific aortic valve stenosis: computational pre-and-post TAVR haemodynamics behaviours.Royal Society open science · 2024Article
- Decoding thrombosis through code: a review of computational models.Journal of thrombosis and haemostasis : JTH · 2024Review
- Effect of Beta Blockers on the Hemodynamics and Thrombotic Risk of Coronary Artery Aneurysms in Kawasaki Disease.Journal of cardiovascular translational research · 2023Article
- Tissue-growth-based synthetic tree generation and perfusion simulation.Biomechanics and modeling in mechanobiology · 2023Article
- A model of fluid-structure and biochemical interactions for applications to subclinical leaflet thrombosis.International journal for numerical methods in biomedical engineering · 2023Article
- Mild Paravalvular Leak May Pose an Increased Thrombogenic Risk in Transcatheter Aortic Valve Replacement (TAVR) Patients-Insights from Patient Specific In Vitro and In Silico Studies.Bioengineering (Basel, Switzerland) · 2023Article
- Biomechanics of Transcatheter Aortic Valve Replacement Complications and Computational Predictive Modeling.Structural heart : the journal of the Heart Team · 2022Review
- Predictive Model for Thrombus Formation After Transcatheter Valve Replacement.Cardiovascular engineering and technology · 2021Article
- Numerical models for assessing the risk of leaflet thrombosis post-transcatheter aortic valve-in-valve implantation.Royal Society open science · 2020Article
- The computational model lifecycle: Opportunities and challenges for computational medicine in the healthcare ecosystem.Science progressReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Leaflet thrombosis has been suggested as the reason for the reduced leaflet motion in cases of hypoattenuated leaflet thickening of bioprosthetic aortic valves. This work aimed to estimate the risk of leaflet thrombosis in two post-valve-in-valve (ViV) configurations, using five different numerical approaches. Realistic ViV configurations were calculated by modelling the deployments of the latest version of transcatheter aortic valve devices (Medtronic Evolut PRO, Edwards SAPIEN 3) in the surgical Sorin Mitroflow. Computational fluid dynamics simulations of blood flow followed the dry models. Lagrangian and Eulerian measures of near-wall stagnation were implemented by particle and concentration tracking, respectively, to estimate the thrombogenicity and to predict the risk locations. Most of the numerical approaches indicate a higher leaflet thrombosis risk in the Edwards SAPIEN 3 device because of its intra-annular implantation. The Eulerian approaches estimated high-risk locations in agreement with the wall sheer stress (WSS) separation points. On the other hand, the Lagrangian approaches predicted high-risk locations at the proximal regions of the leaflets matching the low WSS magnitude regions of both transcatheter aortic valve implantation models and reported clinical and experimental data. The proposed methods can help optimizing future designs of transcatheter aortic valves with minimal thrombotic risks.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.