Evidence map›Paper›PMID 33489165›Full record

ArticleClinical case reports2021

Succinic semialdehyde dehydrogenase deficiency presenting with central hypothyroidism.

Malak Ali Alghamdi, Waleed H Alkhamis, Dima Z Jamjoom, Reem Al Khalifah, Nawaf Rahi Alshammari, Khalid Alsumaili, Stefan T Arold

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical case reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Malak Ali AlghamdiMedical Genetics Division Department of Pediatrics College of Medicine King Saud University Riyadh Saudi Arabia.ORCID https://orcid.org/0000-0002-8317-5951
Waleed H AlkhamisDepartment of Obstetrics and Gynecology King Saud University Medical City Riyadh Saudi Arabia.
Dima Z JamjoomDepartment of Radiology and Medical Imaging College of Medicine King Saud University Riyadh Saudi Arabia.
Reem Al KhalifahPediatric Endocrinology Division Department of Pediatrics College of Medicine King Saud University Riyadh Saudi Arabia.
Nawaf Rahi AlshammariDepartment of Pediatrics College of Medicine King Saud University Riyadh Saudi Arabia.
Khalid AlsumailiBiochemical Genetic Division Department of Pathology College of Medicine King Saud University Riyadh Saudi Arabia.
Stefan T AroldDivision of Biological and Environmental Sciences and Engineering (BESE) King Abdullah University of Science and Technology (KAUST) Computational Bioscience Research Center (CBRC) Thuwal Saudi Arabia.
King Saud University · SAKing Saud Medical City · SAKing Abdullah University of Science and Technology · SA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Central hypothyroidism might be another clinical sign of SSADH deficiency which prompts urinary organic acid screening for GHB in central hypothyroidism patients. Studies on GABA and thyroid hormone interaction might be a concept of a new therapy.

Indexed as

ALDH5A1central hypothyroidismdevelopmental delaysuccinic semialdehyde dehydrogenase deficiency

Identifiers

PMID33489165
PMCPMC7813088
OpenAlexW3105353602

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.