Evidence map›Paper›PMID 33489103›Full record

ArticleHealth information science and systems2021

Epidemiological investigation of a COVID-19 family cluster outbreak transmitted by a 3-month-old infant.

Guo-Tian Lin, Yue-Hua Zhang, Mei-Fang Xiao, Yong Wei, Jin-Ni Chen, Dao-Jiong Lin, Jia-Chong Wang, Qiu-Yu Lin, Zhi-Xian Lei, Zhen-Qiong Zeng and 9 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Health information science and systems, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. COVID-19 transmission: a rapid systematic review of current knowledge.Osong public health and research perspectives · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 5 institutions in 1 country.

Guo-Tian Lin *Laboratory of Tropical Enviroment and Health, School of Public Health, Hainan Medical University, No. 3, Chengxi Xue yuan Road, Longhua District, Haikou, 571199 China.
Yue-Hua Zhang *Department of Child Infectious Diseases, Haikou People's Hospital, Central South University Xiangya School of Medicine Affiliated Haikou Hospital, Haikou, 570203 China.
Mei-Fang Xiao *Hainan Women and Children's Medical Center, Children's Hospital of Fudan University at Hainan, Children's Hospital of Hainan Medical University, Haikou, 570311 China.
Yong WeiHainan Women and Children's Medical Center, Children's Hospital of Fudan University at Hainan, Children's Hospital of Hainan Medical University, Haikou, 570311 China.
Jin-Ni ChenHainan Women and Children's Medical Center, Children's Hospital of Fudan University at Hainan, Children's Hospital of Hainan Medical University, Haikou, 570311 China.
Dao-Jiong LinHainan Women and Children's Medical Center, Children's Hospital of Fudan University at Hainan, Children's Hospital of Hainan Medical University, Haikou, 570311 China.
Jia-Chong WangDepartment of Child Infectious Diseases, Haikou People's Hospital, Central South University Xiangya School of Medicine Affiliated Haikou Hospital, Haikou, 570203 China.
Qiu-Yu LinHainan Women and Children's Medical Center, Children's Hospital of Fudan University at Hainan, Children's Hospital of Hainan Medical University, Haikou, 570311 China.
Zhi-Xian LeiHainan Women and Children's Medical Center, Children's Hospital of Fudan University at Hainan, Children's Hospital of Hainan Medical University, Haikou, 570311 China.
Zhen-Qiong ZengDepartment of Child Infectious Diseases, Haikou People's Hospital, Central South University Xiangya School of Medicine Affiliated Haikou Hospital, Haikou, 570203 China.
Ling LiDepartment of Child Infectious Diseases, Haikou People's Hospital, Central South University Xiangya School of Medicine Affiliated Haikou Hospital, Haikou, 570203 China.
Hong-Ai LiDepartment of Child Infectious Diseases, Haikou People's Hospital, Central South University Xiangya School of Medicine Affiliated Haikou Hospital, Haikou, 570203 China.
Ying ZhengHainan Women and Children's Medical Center, Children's Hospital of Fudan University at Hainan, Children's Hospital of Hainan Medical University, Haikou, 570311 China.
Qiu-Qiong LiHainan Women and Children's Medical Center, Children's Hospital of Fudan University at Hainan, Children's Hospital of Hainan Medical University, Haikou, 570311 China.
Huang-Zhen ZhenHainan Women and Children's Medical Center, Children's Hospital of Fudan University at Hainan, Children's Hospital of Hainan Medical University, Haikou, 570311 China.
Yu-Ming JinHainan Provincial Center for Disease Control and Prevention, Haikou, 570203 China.
Qing-Xia WuDepartment of Child Infectious Diseases, Haikou People's Hospital, Central South University Xiangya School of Medicine Affiliated Haikou Hospital, Haikou, 570203 China.
Fan ZhangLaboratory of Tropical Enviroment and Health, School of Public Health, Hainan Medical University, No. 3, Chengxi Xue yuan Road, Longhua District, Haikou, 571199 China.
Wei XiangKey Laboratory of Tropical Translational Medicine of Ministry of Education, Hainan Medical University, NHC Key Laboratory of Control of Tropical diseases (Hainan Medical University), Haikou, 571199 China.
Hainan Medical University · CNCentral South University · CNHaikou City People's Hospital · CNChildren's Hospital of Fudan University · CNHainan Center for Disease Control & Prevention · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate the clinical characteristics, epidemiological characteristics, and transmissibility of coronavirus disease 2019 (COVID-19) in a family cluster outbreak transmitted by a 3-month-old confirmed positive infant.

methodsField-based epidemiological methods were used to investigate cases and their close contacts. Real-time fluorescent reverse transcription polymerase chain reaction (RT-PCR) was used to detect Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) for all collected specimens. Serum SARS-CoV-2 IgM and IgG antibodies were detected by Chemiluminescence and Gold immnnochromatography (GICA).

resultsThe outbreak was a family cluster with an attack rate of 80% (4/5). The first case in this family was a 3-month-old infant. The transmission chain was confirmed from infant to adults (her father, mother and grandmother). Fecal tests for SARS-CoV-2 RNA remained positive for 37 days after the infant was discharged. The infant's grandmother was confirmed to be positive 2 days after the infant was discharged from hospital. Patients A (3-month-old female), B (patient A's father), C (patient A's grandmother), and D (patient A's mother) had positive serum IgG and negative IgM, but patients A's grandfather serum IgG and IgM were negative.

conclusionSARS-CoV-2 has strong transmissibility within family settings and presence of viral RNA in stool raises concern for possible fecal-oral transmission. Hospital follow-up and close contact tracing are necessary for those diagnosed with COVID-19.

Indexed as

COVID-19Family clusterInfantSerum antibodies

Identifiers

PMID33489103
PMCPMC7812712
OpenAlexW3122555508

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.