Evidence map›Paper›PMID 33489045›Full record

ReviewMediterranean journal of hematology and infectious diseases2021

Socioeconomic Status is Globally a Prognostic Factor for Overall Survival of Multiple Myeloma Patients: Synthesis of Studies and Review of the Literature.

Stergios Intzes, Marianthi Symeonidou, Konstantinos Zagoridis, Zoe Bezirgianidou, Georgios Vrachiolias, Athina Spanoudaki, Emmanouil Spanoudakis

Open access · goldAbstract readReview
In one paragraph

Review in Mediterranean journal of hematology and infectious diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.0field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Real World Multiple Myeloma Registry from Jordan, a Developing Country.Mediterranean journal of hematology and infectious diseases · 2022
    Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Stergios IntzesDemocritus University of Thrace, Medical School, Department of Hematology. Alexandroupolis, Greece.
Marianthi SymeonidouDemocritus University of Thrace, Medical School, Department of Hematology. Alexandroupolis, Greece.
Konstantinos ZagoridisDemocritus University of Thrace, Medical School, Department of Hematology. Alexandroupolis, Greece.
Zoe BezirgianidouDemocritus University of Thrace, Medical School, Department of Hematology. Alexandroupolis, Greece.
Georgios VrachioliasDemocritus University of Thrace, Medical School, Department of Hematology. Alexandroupolis, Greece.
Athina SpanoudakiDemocritus University of Thrace, Medical School, Department of Hematology. Alexandroupolis, Greece.
Emmanouil SpanoudakisDemocritus University of Thrace, Medical School, Department of Hematology. Alexandroupolis, Greece.
Democritus University of Thrace · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSocioeconomic status (SES) is reflecting differences in sociodemographic factors affecting cancer survivorship. Deprived, low SES populations have a higher prevalence of multiple myeloma and worst survival, a condition which widens over time.

methodsWe performed a meta-analysis of 16 studies (registries and cohorts) reporting myeloma patients' survival data according to SES. Ten studies reported Hazzard Ratio (H.R.) (95 % CI), and 16 studies reported p values. We combined the H.R. from 10 studies, and by using the Mosteller-Bush formula, we performed a synthesis of p values according to the area of the globe.

resultsCombination of H.R. from 10 studies including 85198 myeloma patients weighted to sample size of each study and adopting the hypothesis of random effect returned a combined H.R.: 1,26 (1,13-1,31) in favor of high SES patients.USA: Synthesis of p values coming from 6 studies (n=89807 pts) by using the Mosteller and Bush formula extracted a p-value of <0.0001 favoring high SES patients.Oceania: Synthesis of p values in two cohorts from Australia and New Zealand (n= 10196 pts) returned a p-value of 0,022 favoring high SES patients.Europe: The synthesis of p values from the U.K. and Greece studies (n=18533 pts) returned a p-value of <0,0001 favoring high SES patients.Asia: Synthesis of 2 studies from Asia (n=915 pts) returned a p-value of <0,0001 favoring high SES patients.

conclusionsAcross the globe and widening over decades, the socioeconomic status remains a gap for equality in myeloma care.

Indexed as

MyelomaSocioeconomic status

Identifiers

PMID33489045
PMCPMC7813274
OpenAlexW3119310262

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.