Evidence map›Paper›PMID 33489044›Full record

ArticleMediterranean journal of hematology and infectious diseases2021

Donor KIR3DL1/receptor HLA-Bw4-80I Combination Reduces Acute Leukemia Relapse after Umbilical Cord Blood Transplantation without in Vitro T-cell Depletion.

Xinchen Fang, Xiaoyu Zhu, Baolin Tang, Kaidi Song, Wen Yao, Xiang Wan, Huilan Liu, Jun Peng, Zimin Sun

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Mediterranean journal of hematology and infectious diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Trial
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Xinchen FangDepartment of Hematology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, No. 27 Shanda South Road, Jinan, Shandong, 250012, China.
Xiaoyu ZhuDepartment of Hematology, The First Affiliated Hospital of University of Science and Technology of China, Hefei, Anhui, 230001, China.
Baolin TangDepartment of Hematology, The First Affiliated Hospital of University of Science and Technology of China, Hefei, Anhui, 230001, China.
Kaidi SongDepartment of Hematology, The First Affiliated Hospital of University of Science and Technology of China, Hefei, Anhui, 230001, China.
Wen YaoDepartment of Hematology, The First Affiliated Hospital of University of Science and Technology of China, Hefei, Anhui, 230001, China.
Xiang WanDepartment of Hematology, The First Affiliated Hospital of University of Science and Technology of China, Hefei, Anhui, 230001, China.
Huilan LiuDepartment of Hematology, The First Affiliated Hospital of University of Science and Technology of China, Hefei, Anhui, 230001, China.
Jun PengDepartment of Hematology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, No. 27 Shanda South Road, Jinan, Shandong, 250012, China.
Zimin SunDepartment of Hematology, The First Affiliated Hospital of University of Science and Technology of China, Hefei, Anhui, 230001, China.
Qilu Hospital of Shandong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDonor natural killer (NK) cell alloreactivity in umbilical cord bone marrow transplantation (UCBT) can lead to leukemic relapse. However, NK cell function is calibrated by interaction with human leukocyte antigens (HLAs). This study aimed to investigate graft-resistant leukemia after transplantation and compared specific genotypes of killer immunoglobulin-like receptors (KIRs) in donors and human leukocyte antigen ligands in patients.

methodsWe retrospectively analyzed 232 patients with acute leukemia from a single center. Patients had undergone UCBT with myeloablative conditioning and without anti-thymocyte globulin. We identified the KIR genotypes of cord blood donors using polymerase chain reaction with sequence-specific primers. All of the donors contained KIR3DL1.

resultsThe patients were divided into three groups according to the HLA-B locus. The donor KIR3DL1 and recipient HLA-Bw4-80I combination was predictive of being highly educated and was associated with a lower relapse (

conclusionsOur data suggest that the donor KIR3DL1/receptor and HLA-Bw4-80I combination in UCBT results in stronger graft-versus-leukemia effects and improved outcomes in patients with acute leukemia.

Indexed as

Acute lymphocytic leukemiaAcute myeloid leukemiaKiller immunoglobulin-like receptorsNatural killer cellsUmbilical cord blood transplantation

Identifiers

PMID33489044
PMCPMC7813285
OpenAlexW3118412781

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.