Evidence map›Paper›PMID 33488937›Full record

ArticleOxidative medicine and cellular longevity2020

Ophiopogonin D Increases SERCA2a Interaction with Phospholamban by Promoting CYP2J3 Upregulation.

Jia Wang, Wenting You, Ningning Wang, Wei Zhou, Yunxuan Ge, Zengchun Ma, Hongling Tan, Yuguang Wang, Yue Gao

Open access · hybridAbstract read
In one paragraph

Article in Oxidative medicine and cellular longevity, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
6.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 86 citations in OpenAlex.

  1. Article
  2. Review
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  6. L-Borneol 7-O-[Journal of immunology research · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Jia WangDepartment of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, Beijing 100850, China.
Wenting YouDepartment of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, Beijing 100850, China.
Ningning WangDepartment of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, Beijing 100850, China.
Wei ZhouDepartment of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, Beijing 100850, China.
Yunxuan GeDepartment of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, Beijing 100850, China.
Zengchun MaDepartment of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, Beijing 100850, China.
Hongling TanDepartment of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, Beijing 100850, China.
Yuguang WangDepartment of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, Beijing 100850, China.ORCID https://orcid.org/0000-0001-9149-9107
Yue GaoDepartment of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, Beijing 100850, China.ORCID https://orcid.org/0000-0003-1131-5326
Guangdong Pharmaceutical University · CNAnhui Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ophiopogonin D (OPD), a compound from the Chinese herb Radix Ophiopogonis, reportedly induces increased levels of cytochrome P450 2J3 (CYP2J3)/epoxyeicosatrienoic acids (EETs) and Ca

Indexed as

AnimalsApoptosisCalciumCalcium-Binding ProteinsCardiotonic AgentsCytochrome P-450 Enzyme SystemGene Expression RegulationHeart FailureIsoproterenolMyocytes, CardiacOxidation-ReductionPhospholambanRatsSaponinsSarcoplasmic ReticulumSarcoplasmic Reticulum Calcium-Transporting ATPasesAtp2a2 protein, mouseCalciumCalcium-Binding ProteinsCardiotonic AgentsCyp2j3 protein, ratCytochrome P-450 Enzyme SystemIsoproterenolophiopogonin DPhospholambanSaponinsSarcoplasmic Reticulum Calcium-Transporting ATPasesSpirostans

Identifiers

PMID33488937
PMCPMC7790559
OpenAlexW3115701603

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.