Evidence map›Paper›PMID 33488736›Full record

ReviewStem cells international2020

Adipose-Derived Stem Cells: Current Applications and Future Directions in the Regeneration of Multiple Tissues.

Jiaxin Zhang, Yuzhe Liu, Yutong Chen, Lei Yuan, He Liu, Jincheng Wang, Qiran Liu, Yan Zhang

Abstract readReview
In one paragraph

Review in Stem cells international, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 132 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
132citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

132 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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  17. Efficacy of the combination of umbilical fat and venous blood on limb salvage.Frontiers in bioengineering and biotechnology · 2026
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72 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jiaxin ZhangDepartment of Breast Surgery, The Second Hospital of Jilin University, Changchun 130041, China.ORCID https://orcid.org/0000-0002-4455-0093
Yuzhe LiuOrthopaedic Medical Center, The Second Hospital of Jilin University, Changchun 130041, China.ORCID https://orcid.org/0000-0003-2969-7131
Yutong ChenDepartment of Breast Surgery, The Second Hospital of Jilin University, Changchun 130041, China.ORCID https://orcid.org/0000-0003-1728-6597
Lei YuanDepartment of Cardiovascular Surgery, The Second Hospital of Jilin University, Changchun 130041, China.ORCID https://orcid.org/0000-0003-4622-3106
He LiuOrthopaedic Medical Center, The Second Hospital of Jilin University, Changchun 130041, China.ORCID https://orcid.org/0000-0001-7178-0276
Jincheng WangOrthopaedic Medical Center, The Second Hospital of Jilin University, Changchun 130041, China.ORCID https://orcid.org/0000-0002-1217-5962
Qiran LiuDepartment of Breast Surgery, The Second Hospital of Jilin University, Changchun 130041, China.ORCID https://orcid.org/0000-0003-3866-1325
Yan ZhangDepartment of Breast Surgery, The Second Hospital of Jilin University, Changchun 130041, China.ORCID https://orcid.org/0000-0003-0790-913X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adipose-derived stem cells (ADSCs) can maintain self-renewal and enhanced multidifferentiation potential through the release of a variety of paracrine factors and extracellular vesicles, allowing them to repair damaged organs and tissues. Consequently, considerable attention has increasingly been paid to their application in tissue engineering and organ regeneration. Here, we provide a comprehensive overview of the current status of ADSC preparation, including harvesting, isolation, and identification. The advances in preclinical and clinical evidence-based ADSC therapy for bone, cartilage, myocardium, liver, and nervous system regeneration as well as skin wound healing are also summarized. Notably, the perspectives, potential challenges, and future directions for ADSC-related researches are discussed. We hope that this review can provide comprehensive and standardized guidelines for the safe and effective application of ADSCs to achieve predictable and desired therapeutic effects.

Identifiers

PMID33488736
PMCPMC7787857

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.