Evidence map›Paper›PMID 33488611›Full record

ArticleFrontiers in immunology2020

Genetic Dissection of the Regulatory Mechanisms of

Fuyi Xu, Jun Gao, Silke Bergmann, Amy C Sims, David G Ashbrook, Ralph S Baric, Yan Cui, Colleen B Jonsson, Kui Li, Robert W Williams and 2 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 3 countries.

Fuyi XuDepartment of Genetics, Genomics, and Informatics, University of Tennessee Health Science Center, Memphis, TN, United States.
Jun GaoDepartment of Genetics, Genomics, and Informatics, University of Tennessee Health Science Center, Memphis, TN, United States.
Silke BergmannDepartment of Microbiology, Immunology, and Biochemistry, University of Tennessee Health Science Center, Memphis, TN, United States.
Amy C SimsDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
David G AshbrookDepartment of Genetics, Genomics, and Informatics, University of Tennessee Health Science Center, Memphis, TN, United States.
Ralph S BaricDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
Yan CuiDepartment of Genetics, Genomics, and Informatics, University of Tennessee Health Science Center, Memphis, TN, United States.
Colleen B JonssonDepartment of Microbiology, Immunology, and Biochemistry, University of Tennessee Health Science Center, Memphis, TN, United States.
Kui LiDepartment of Microbiology, Immunology, and Biochemistry, University of Tennessee Health Science Center, Memphis, TN, United States.
Robert W WilliamsDepartment of Genetics, Genomics, and Informatics, University of Tennessee Health Science Center, Memphis, TN, United States.
Klaus SchughartDepartment of Microbiology, Immunology, and Biochemistry, University of Tennessee Health Science Center, Memphis, TN, United States.
Lu LuDepartment of Genetics, Genomics, and Informatics, University of Tennessee Health Science Center, Memphis, TN, United States.
University of Tennessee Health Science Center · USUniversity of North Carolina at Chapel Hill · USHelmholtz Centre for Infection Research · DEShanghai Academy of Agricultural Sciences · CN

Funding

Unlocking Zika Virus Immune Control and Pathogenesis with the Collaborative CrossU19AI100625 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MCWEENEY, SHANNON K. · 2012 to 2021
$36.6M
Translational CoreU19AI109761 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI LIPKIN, W. IAN · 2014 to 2018
$32.6M
Vector CoreP30DK065988 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Martina Gentzsch · 2004 to 2026
$26.5M
Respiratory Virus Vaccine and Adjuvant Exploration - Equipment SupplementU01AI149644 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BARIC, RALPH S · 2019 to 2023
$6.1M
A Unified High Performance Web Service for Systems Genetics and Precision MedicineR01GM123489 · NIGMS · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI PRINS, PJOTR, SEN, SAUNAK · 2017 to 2024
$3.7M
NIAID NIH HHS U19 AI100625NIAID NIH HHS U19 AI109761NIGMS NIH HHS R01 GM123489
6 · The paper itself

Abstract

Acute lung injury (ALI) is an important cause of morbidity and mortality after viral infections, including influenza A virus H1N1, SARS-CoV, MERS-CoV, and SARS-CoV-2. The angiotensin I converting enzyme 2 (ACE2) is a key host membrane-bound protein that modulates ALI induced by viral infection, pulmonary acid aspiration, and sepsis. However, the contributions of

Indexed as

Angiotensin-Converting Enzyme 2AnimalsBayes TheoremEpithelial CellsFemaleHumansLungMiceMice, Inbred C57BLMice, Inbred DBARespiratory MucosaSignal TransductionVirus DiseasesAce2 protein, mouseAngiotensin-Converting Enzyme 2Ace2acute lung injuryBXD familyH1N1host responseviremia network

Identifiers

PMID33488611
PMCPMC7819859
OpenAlexW3120626853

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.