Evidence map›Paper›PMID 33488578›Full record

ArticleFrontiers in immunology2020

CD80 on Human T Cells Is Associated With FoxP3 Expression and Supports Treg Homeostasis.

Blagoje Soskic, Louisa E Jeffery, Alan Kennedy, David H Gardner, Tie Zheng Hou, Neil Halliday, Cayman Williams, Daniel Janman, Behzad Rowshanravan, Gideon M Hirschfield and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 49 citations in OpenAlex.

  1. Review
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  14. Review
  15. Loss of ADAP1/CentA1 Protects Against Autoimmune Demyelination.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Article
  16. Article
  17. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Blagoje SoskicInstitute of Immunity and Transplantation, Division of Infection & Immunity, University College London, Royal Free Hospital, London, United Kingdom.
Louisa E JefferyInstitute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham, United Kingdom.
Alan KennedyInstitute of Immunity and Transplantation, Division of Infection & Immunity, University College London, Royal Free Hospital, London, United Kingdom.
David H GardnerSchool of Immunity and Infection, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham, United Kingdom.
Tie Zheng HouInstitute of Immunity and Transplantation, Division of Infection & Immunity, University College London, Royal Free Hospital, London, United Kingdom.
Neil HallidayInstitute of Immunity and Transplantation, Division of Infection & Immunity, University College London, Royal Free Hospital, London, United Kingdom.
Cayman WilliamsInstitute of Immunity and Transplantation, Division of Infection & Immunity, University College London, Royal Free Hospital, London, United Kingdom.
Daniel JanmanInstitute of Immunity and Transplantation, Division of Infection & Immunity, University College London, Royal Free Hospital, London, United Kingdom.
Behzad RowshanravanInstitute of Immunity and Transplantation, Division of Infection & Immunity, University College London, Royal Free Hospital, London, United Kingdom.
Gideon M HirschfieldToronto Centre for Liver Disease, Toronto General Hospital, Toronto, ON, Canada.
David M SansomInstitute of Immunity and Transplantation, Division of Infection & Immunity, University College London, Royal Free Hospital, London, United Kingdom.
The Royal Free Hospital · GBUniversity College London · GBUniversity of Birmingham · GBToronto General Hospital · CA

Funding

Arthritis Research UK 19364Biotechnology and Biological Sciences Research Council BB/M009203/1Department of HealthVersus Arthritis 21147Wellcome Trust 110297/Z/15/ZWellcome Trust 20478/Z/16
6 · The paper itself

Abstract

CD80 and CD86 are expressed on antigen presenting cells (APCs) and their role in providing costimulation to T cells is well established. However, it has been shown that these molecules can also be expressed by T cells, but the significance of this observation remains unknown. We have investigated stimuli that control CD80 and CD86 expression on T cells and show that in APC-free conditions around 40% of activated, proliferating CD4

Indexed as

Cell ProliferationLymphocyte ActivationAnimalsB7-1 AntigenB7-2 AntigenCalcitriolCD28 AntigensCHO CellsCricetulusCTLA-4 AntigenForkhead Transcription FactorsHomeostasisHumansInterferon-gammaInterleukin-2Signal TransductionB7-1 AntigenB7-2 AntigenCalcitriolCD28 AntigensCD80 protein, humanCD86 protein, humanCTLA-4 AntigenCTLA4 protein, humanForkhead Transcription FactorsFOXP3 protein, humanIFNG protein, humanInterferon-gammaInterleukin-2SirolimusTransforming Growth Factor betaCD28 costimulationCD80 and CD86CTLA-4T cell activationTreg

Identifiers

PMID33488578
PMCPMC7820758
OpenAlexW3120003695

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.