ArticleFrontiers in psychiatry2020
Pluripotential Risk and Clinical Staging: Theoretical Considerations and Preliminary Data From a Transdiagnostic Risk Identification Approach.
Article in Frontiers in psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 3 of them syntheses that pooled it.
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Who cites it
43 citing papers in PubMed, 3 syntheses or guidelines pooled it, 80 citations in OpenAlex.
- Eating disorders and disordered eating symptoms in individuals at clinical high risk for psychosis: a systematic review and meta-analysis.Eating and weight disorders : EWD · 2024Pooled it
- The progress in the field of clinical staging for mental disorders within the last decade: an updated systematic review.Frontiers in psychiatry · 2024Pooled it
- Neuropsychological Performance Among Individuals at Clinical High-Risk for Psychosis vs Putatively Low-Risk Peers With Other Psychopathology: A Systematic Review and Meta-Analysis.Schizophrenia bulletin · 2022Pooled it
- Effect of 3 Forms of Early Intervention for Young People With Borderline Personality Disorder: The MOBY Randomized Clinical Trial.JAMA psychiatry · 2022Trial
- Odyssée: protocol for a prospective cohort on psychiatric transition at age 17 in Nice, France.BMJ open · 2026Article
- Candidate Targets for Resilience Training to Reduce Transdiagnostic Risk for Mental Illness.Schizophrenia bulletin · 2026Article
- Article
- Co-existence of clinical high-risk for psychosis and bipolar disorder: a multi-dimensional psychopathological analysis.BMC psychiatry · 2026Article
- Genetic sensitivity to the environment moderates the impact of positive and negative childhood experiences on psychological adjustment "for good and for bad".European psychiatry : the journal of the Association of European Psychiatrists · 2026Article
- Traumatic and stressful life events as precipitants of obsessive compulsive disorder and social anxiety disorder.Journal of traumatic stress · 2026Article
- Transdiagnostic prevention in youth mental health, Part I: rationale, shared risk factors.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Feasibility of a Stepped-Care Intervention for Those at Clinical High Risk for Psychosis in the United States.Early intervention in psychiatry · 2026Article
- Transdiagnostic prevention in youth mental health, Part II: interventions.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Article
- Developing Trace: A Transdiagnostic Screening Tool for Early Detection of a Pluripotent at-Risk Mental State.International journal of methods in psychiatric research · 2025Article
- Borderline Personality Disorder or First-Episode Psychosis? Challenges in Assessing Psychotic Features in Early Intervention: A Case Report.Early intervention in psychiatry · 2025Article
- Longitudinal Trajectories of Clinical Features in Community Youth With Recurrent Psychosis Spectrum Symptoms: Findings From the Philadelphia Neurodevelopmental Cohort.Schizophrenia bulletin · 2025Article
- Longitudinal evolution of the transdiagnostic prodrome to severe mental disorders: a dynamic temporal network analysis informed by natural language processing and electronic health records.Molecular psychiatry · 2025Article
- Article
- Investigating the associations between personality functioning, cognitive biases, and (non-)perceptive clinical high-risk symptoms of psychosis in the community.European psychiatry : the journal of the Association of European Psychiatrists · 2025Article
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Most psychiatric disorders develop during adolescence and young adulthood and are preceded by a phase during which attenuated or episodic symptoms and functional decline are apparent. The introduction of the ultra-high risk (UHR) criteria two decades ago created a new framework for identification of risk and for pre-emptive psychiatry, focusing on first episode psychosis as an outcome. Research in this paradigm demonstrated the comorbid, diffuse nature of emerging psychopathology and a high degree of developmental heterotopy, suggesting the need to adopt a broader, more agnostic approach to risk identification. Guided by the principles of clinical staging, we introduce the concept of a pluripotent at-risk mental state. The clinical high at risk mental state (CHARMS) approach broadens identification of risk beyond psychosis, encompassing multiple exit syndromes such as mania, severe depression, and personality disorder. It does not diagnostically differentiate the early stages of psychopathology, but adopts a "pluripotent" approach, allowing for overlapping and heterotypic trajectories and enabling the identification of both transdiagnostic and specific risk factors. As CHARMS is developed within the framework of clinical staging, clinical utility is maximized by acknowledging the dimensional nature of clinical phenotypes, while retaining thresholds for introducing specific interventions. Preliminary data from our ongoing CHARMS cohort study (
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