ReviewFrontiers in psychiatry2020
Premature Birth and Developmental Programming: Mechanisms of Resilience and Vulnerability.
Review in Frontiers in psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
79 citing papers in PubMed, 2 syntheses or guidelines pooled it, 127 citations in OpenAlex.
- Heart rate variability after hospital discharge in perinatal risk populations: a systematic review and meta-analysis.Pediatric research · 2026Pooled it
- Effect of music therapy on behavioral and physiological neonatal outcomes: A systematic review and dose-response meta-analysis.PloS one · 2025Pooled it
- Moderate-To-Late Preterm Infants Benefit From the Early Collaborative Intervention: Primary Outcomes of an RCT.Acta paediatrica (Oslo, Norway : 1992) · 2025Trial
- An exploratory study of clinical factors associated with IGF-1 and IGFBP-3 in preterm infants.Pediatric research · 2024Trial
- Regulation of Stress Physiology Across Social Contexts in Preterm-Born Preschoolers.Psychophysiology · 2026Article
- Trace Element Dyshomeostasis as a Mediator of Toxic Metal-Induced Reproductive Dysfunction: Mechanistic Insights and Future Perspectives.Biological trace element research · 2026Review
- Hybrid additive manufacturing-based assembly of sacrificial isomalt scaffolds and gas exchange membranes for microfluidic artificial lung development.Microsystems & nanoengineering · 2026Article
- Glucocorticoid trajectories in preterm infants-born too soon, wired differently.The Journal of clinical endocrinology and metabolism · 2026Article
- Relevance of prematurity and foetal growth restriction for romantic relationships, health-risk behaviours, and socio-economic outcomes in adulthood.European journal of public health · 2026Article
- Prenatal exposure to perfluoroalkyl sulfonic and carboxylic acids and neurodevelopmental delay in children up to 5 years old: Effect modification by progesterone and estradiol.Eco-Environment & Health · 2026Article
- The Predictive Power of Early Socio-Emotional Skills on Behavioral Outcomes in Very Preterm Preschoolers: A Longitudinal Study.Pediatric reports · 2026Article
- Postnatal Steroids in Preterm Infants: A Narrative Review Series-Part 2: Cardiovascular Impacts.Children (Basel, Switzerland) · 2026Review
- The role of negative affectivity in the developmental pathway linking perinatal complications to behavioral and emotional problems in children.Development and psychopathology · 2026Article
- Diurnal rhythms in melatonin and cortisol in very preterm human milk.Frontiers in nutrition · 2026Article
- Music-based research in neonatal intensive care units requires guidelines grounded in developmental neurology and responsive to the individual needs of preterm infants.Frontiers in psychology · 2026Article
- Educational materials to empower parents of preterm infants within a family-centered early intervention in the NICU.Frontiers in pediatrics · 2026Article
- Stress during the first 1,000 days of life in humans, when everything begins.Frontiers in human neuroscience · 2026Review
- Autonomic nervous system maturation in preterm neonates: Correlation with gestational and postmenstrual age (ProMote).PloS one · 2026Article
- Article
- Dynamic Interactions between the Gut Microbiome, Health, and Metabolic Disorders in Preterm Infants.Journal of microbiology and biotechnology · 2025Review
19 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The third trimester of pregnancy represents a sensitive phase for infant brain plasticity when a series of fast-developing cellular events (synaptogenesis, neuronal migration, and myelination) regulates the development of neural circuits. Throughout this dynamic period of growth and development, the human brain is susceptible to stress. Preterm infants are born with an immature brain and are, while admitted to the neonatal intensive care unit, precociously exposed to stressful procedures. Postnatal stress may contribute to altered programming of the brain, including key systems such as the hypothalamic-pituitary-adrenal axis and the autonomic nervous system. These neurobiological systems are promising markers for the etiology of several affective and social psychopathologies. As preterm birth interferes with early development of stress-regulatory systems, early interventions might strengthen resilience factors and might help reduce the detrimental effects of chronic stress exposure. Here we will review the impact of stress following premature birth on the programming of neurobiological systems and discuss possible stress-related neural circuits and pathways involved in resilience and vulnerability. Finally, we discuss opportunities for early intervention and future studies.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.