Evidence map›Paper›PMID 33488073›Full record

Trial reportInternational journal of chronic obstructive pulmonary disease

Longitudinal FEV

Kirill Zhudenkov, Robert Palmér, Alexandra Jauhiainen, Gabriel Helmlinger, Oleg Stepanov, Kirill Peskov, Ulf G Eriksson, Ulrika Wählby Hamrén

Open access · goldAbstract readClinical Trial
In one paragraph

Trial report in International journal of chronic obstructive pulmonary disease. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Article
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  4. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

Kirill ZhudenkovM&S Decisions LLC, Moscow, Russia.
Robert PalmérClinical Pharmacology & Quantitative Pharmacology, Clinical Pharmacology & Safety Sciences, R&D, AstraZeneca, Gothenburg, Sweden.
Alexandra JauhiainenBioPharma Early Biometrics and Statistical Innovation, Data Science & AI, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.
Gabriel HelmlingerClinical Pharmacology & Quantitative Pharmacology, Clinical Pharmacology & Safety Sciences, R&D, AstraZeneca, Boston, MA, USA.ORCID 0000-0003-4925-2463
Oleg StepanovM&S Decisions LLC, Moscow, Russia.
Kirill PeskovM&S Decisions LLC, Moscow, Russia.
Ulf G ErikssonClinical Pharmacology & Quantitative Pharmacology, Clinical Pharmacology & Safety Sciences, R&D, AstraZeneca, Gothenburg, Sweden.
Ulrika Wählby HamrénClinical Pharmacology & Quantitative Pharmacology, Clinical Pharmacology & Safety Sciences, R&D, AstraZeneca, Gothenburg, Sweden.ORCID 0000-0002-9761-9699
AstraZeneca (Sweden) · SEAstraZeneca (United States) · USSechenov University · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLung function, measured as forced expiratory volume in one second (FEV

objectiveTo evaluate joint modelling as a tool for analyzing treatment effects in COPD clinical trials by quantifying the association between longitudinal improvements in FEV

methodsA joint model of longitudinal FEV

resultsA significant (p<0.0001) association between FEV

conclusionJoint modelling can be used to co-analyze longitudinal FEV

Indexed as

Pulmonary Disease, Chronic ObstructiveAdministration, InhalationBronchodilator AgentsBudesonideDrug CombinationsForced Expiratory VolumeFormoterol FumarateHumansRespiratory Function TestsBronchodilator AgentsBudesonideDrug CombinationsFormoterol Fumarateanti-inflammatorybronchodilatorlung function

Identifiers

PMID33488073
PMCPMC7815071
OpenAlexW3120472076

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.