ArticleNigerian medical journal : journal of the Nigeria Medical Association
Effect of Vitamin D Supplementation on Thyroid Autoimmunity among Subjects of Autoimmune Thyroid Disease in a Coastal Province of India: A Randomized Open-label Trial.
Article in Nigerian medical journal : journal of the Nigeria Medical Association. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- Pooled it
- The Role of Vitamin D in Autoimmune Thyroid Diseases: From Immunomodulation to Clinical Implications.Nutrients · 2026Review
- Vitamin D Receptor Polymorphisms and Immunological Effects of Vitamin D in Hashimoto's Thyroiditis.International journal of molecular sciences · 2025Review
- The development of thyroid autoimmunity is potentially associated with the deficiency of vitamin D3 rather than vitamin D2 in euthyroid men.Thyroid research · 2025Article
- Effects of vitamin D replacement combined with Graves' disease therapy: a retrospective cohort study.Turkish journal of medical sciences · 2025Article
- Review
- Impact of Vitamin D on Immunopathology of Hashimoto's Thyroiditis: From Theory to Practice.Nutrients · 2023Review
- Article
- How does Hashimoto's thyroiditis affect bone metabolism?Reviews in endocrine & metabolic disorders · 2023Review
- The Role of Vitamin D in Autoimmune Thyroid Diseases: A Narrative Review.Journal of clinical medicine · 2023Review
- Metabolic Characteristics of Hashimoto's Thyroiditis Patients and the Role of Microelements and Diet in the Disease Management-An Overview.International journal of molecular sciences · 2022Review
- Vitamin D Implications and Effect of Supplementation in Endocrine Disorders: Autoimmune Thyroid Disorders (Hashimoto's Disease and Grave's Disease), Diabetes Mellitus and Obesity.Medicina (Kaunas, Lithuania) · 2022Review
- Association between Cardiometabolic risk factor and responsiveness to vitamin D supplementation: a new approach using artificial neural network analysis.BMC nutrition · 2021Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveHashimoto's thyroiditis (HT) is a variant of autoimmune thyroid disorders (AITD) which has been associated with vitamin D (vit-D) deficiency. However, whether vit-D supplementation is linked to reduction of thyroid autoantibodies and improvement of thyroid function is not well characterized. The present study was planned to evaluate the effect of vit-D supplementation on possible improvement of thyroid autoantibody titer and thyroid hormone profile in patients with AITD subjects.
methodsTwenty-three patients of HT were given weekly supplementation of 60,000 IU vit-D for 8 weeks followed by once a month for another 4 months. After 6 months of vit-D supplementation, thyroid autoantibody titer (TPO antibody) and thyroid hormone profile was rechecked.
resultsMean serum vit-D was increased significantly from 15.33 ± 5.71 to 41.22 ± 12.24 ng/mL (normal levels) after supplementation. There was significant increase in thyroid autoantibody titre (from 746.8 ± 332.2 to 954.1 ±4 59.8 IU/ml;
conclusionVitamin-D levels were low in AITD patients in eastern India and, its supplementation in HT patients increased thyroid antibody titer and there was significant reduction in serum TSH and increased in free T4.
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Registered trials
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