ArticleAnesthesia, essays and researches
Comparison of Blood-Conserving and Allogenic Transfusion-Sparing Effects of Antifibrinolytics in Scoliosis Correction Surgery.
Article in Anesthesia, essays and researches. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
4 citing papers in PubMed, 7 citations in OpenAlex.
- Article
- Blood Management and Conservation During Adult Spine Deformity Surgery.Global spine journal · 2025Article
- Clinical Effects of Intraoperative Use of Tranexamic Acid in Minimally Invasive Scoliosis Surgery for Adolescent Idiopathic Scoliosis.Clinics in orthopedic surgery · 2024Article
- Is High-Dose Tranexamic Safe in Spine Surgery? A Systematic Review and Meta-Analysis.Global spine journal · 2023Article
Corrections and comments
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Authors and funding
4 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIntraoperative antifibrinolytic drug administration is a safe and effective method of reducing blood loss and allogenic transfusions in patients undergoing spine deformity correction.
aimThis study aimed to compare the effectiveness of two antifibrinolytic drugs tranexamic acid (TXA) and epsilon amino caproic acid (EACA) in reducing peri-operative blood loss and transfusion requirements against a placebo control in patients with idiopathic scoliosis undergoing correction surgery. SETTING AND
designThis is a prospective, randomized, double-blinded, controlled comparative study. METHODOLOGY: Patients in TXA group received 50 mg.kg STATISTICAL ANALYSIS: Mean and standard deviation were used to represent the quantitative continuous data, and percentage was used to represent categorical data. The Student's
resultsA total of 36 patients were enrolled with 12 patients in each group. Peri-operative blood loss was 50.1% lower in patients receiving TXA and 17.7% lower in patients receiving EACA compared with the placebo group. The volume of total packed red cell transfusion was 66.7% lower in patients receiving TXA and 45.6% lower in patients receiving EACA compared with placebo.
conclusionTXA was more effective in reducing total peri-operative blood loss and allogenic transfusion requirement in idiopathic scoliosis correction surgery compared to EACA.
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Registered trials
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