ArticleAnesthesia, essays and researches
Dexmedetomidine and Ketamine as an Adjuvant to Levobupivacaine for Pediatric Caudal Analgesia: A Randomized, Controlled Study.
Article in Anesthesia, essays and researches. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed, 5 citations in OpenAlex.
- Dexmedetomidine versus ketamine for preemptive caudal analgesia in single-level lumbar laminectomy: A randomized controlled trial.Medicine · 2025Trial
- Methods of prolonging the effect of caudal block in children.Frontiers in pediatrics · 2024Review
- Article
- Review of clinical evidence of caudal block for postoperative analgesia in children with ketamine added local anesthetics.Annals of medicine and surgery (2012) · 2022Review
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundKetamine and dexmedetomidine as an adjuvant to caudal block are used in the pediatric population.
aimsWe aimed to compare the analgesic and safety profile of dexmedetomidine with ketamine for single-shot caudal block. SETTINGS AND
designThis was a randomized controlled study conducted in a tertiary care university hospital. MATERIALS AND
methodsNinety patients admitted for routine infraumbilical surgical procedures under general anesthesia were enrolled in this double-blind randomized study. Following caudal block under general anesthesia, patients were allocated to one of three groups; Group LS received 0.75 mL.kg STATISTICAL ANALYSIS USED: Categorical data were analyzed by Chi-squire test and numerical continuous data were analyzed by Student's
resultsThe addition of dexmedetomidine and ketamine to levobupivacaine resulted in significant prolongation of postoperative analgesia duration (467 min and 385 min, respectively) compared with 0.25% levobupivacaine alone (276 min). No significant side effects requiring intervention were observed in any group.
conclusionsDexmedetomidine as an adjuvant to levobupivacaine provides a longer duration of analgesia as compared to ketamine without any significant side effect.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.