Evidence map›Paper›PMID 33487617›Full record

Observational studyJournal of atherosclerosis and thrombosis2022

Relationship of Four Blood Pressure Indexes to Subclinical Cerebrovascular Diseases Assessed by Brain MRI in General Japanese Men.

Ebtehal Salman, Aya Kadota, Takashi Hisamatsu, Hiroyoshi Segawa, Sayuki Torii, Akira Fujiyoshi, Keiko Kondo, Yoshiyuki Watanabe, Hisatomi Arima, Akihiko Shiino and 3 more

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PubMed Full text at PMC Publisher
In one paragraph

Observational study in Journal of atherosclerosis and thrombosis, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Observational
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Ebtehal SalmanDepartment of Public Health, Shiga University of Medical Science.
Aya KadotaDepartment of Public Health, Shiga University of Medical Science.
Takashi HisamatsuDepartment of Public Health, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University.
Hiroyoshi SegawaDepartment of Public Health, Shiga University of Medical Science.
Sayuki ToriiDepartment of Public Health, Shiga University of Medical Science.
Akira FujiyoshiDepartment of Public Health, Shiga University of Medical Science.
Keiko KondoDepartment of Public Health, Shiga University of Medical Science.
Yoshiyuki WatanabeDepartment of Radiology, Shiga University of Medical Science.
Hisatomi ArimaDepartment of Preventive Medicine and Public Health, Faculty of Medicine, Fukuoka University.
Akihiko ShiinoMolecular Neuroscience Research Center, Shiga University of Medical Science.
Kazuhiko NozakiDepartment of Neurosurgery, Shiga University of Medical Science.
Hirotsugu UeshimaDepartment of Public Health, Shiga University of Medical Science.
Katsuyuki MiuraDepartment of Public Health, Shiga University of Medical Science.
Shiga University of Medical Science · JPFukuoka University · JPOkayama University · JPShiga University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimThe relationship of blood pressure (BP) indexes (systolic blood pressure [SBP], diastolic blood pressure [DBP], pulse pressure [PP], mean arterial pressure [MAP]) to subclinical cerebrovascular diseases (SCVDs) remains unclear. This study aimed to elucidate the relationship of four BP indexes measured at two visits on SCVDs assessed by magnetic resonance imaging (MRI) in general Japanese men.

methodsIn general Japanese men aged 40-79 years (N=616), office BP indexes were measured at two visits (Visits 1 [2006-2008] and 2 [2010-2014]). MRI images obtained on the third visit (2012-2015) were examined for prevalent SCVDs: lacunar infarction, periventricular hyperintensity (PVH), deep subcortical white matter hyperintensity (DSWMH), microbleeds, and intracranial artery stenosis (ICAS). Using a multivariable logistic regression analysis, we computed and estimated the odds ratio of each prevalent SCVD for one standard deviation higher BP indexes. The same analyses were performed using home BP.

resultsAll four office BP indexes at both visits associated with lacunar infarction. Visit 1 and 2 DBP and Visit 1 MAP associated with PVH and DSWMH, and Visit 1 SBP associated with DSWMH. All Visit 2 BP indexes appear to show stronger association with microbleeds than Visit 1 indexes, and Visit 1 and 2 SBP, PP, and MAP showed similar associations with ICAS. Additional analyses using home BP indexes revealed similar relationships; however, the significance of some relationships decreased.

conclusionIn general Japanese men, BP indexes were associated with most of SCVDs, and BP indexes measured at different periods associated with different SCVDs assessed by MRI.

Indexed as

Magnetic Resonance ImagingAdultAgedBlood PressureCerebrovascular DisordersCohort StudiesHumansJapanLogistic ModelsMaleMiddle AgedOdds RatioRisk FactorsBlood pressure indexesBrain magnetic resonance imagingHome blood pressureJapaneseSubclinical cerebrovascular diseases

Identifiers

PMID33487617
PMCPMC8803566
OpenAlexW3123459585

What OpenQuestion holds

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LicenceCC BY-NC-SA
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.