Evidence map›Paper›PMID 33487126›Full record

Trial reportJournal of neurotrauma2021

Brain Magnetic Resonance Imaging Volumetric Measures of Functional Outcome after Severe Traumatic Brain Injury in Adolescents.

Peter Ferrazzano, Benjamin Yeske, Jeanette Mumford, Gregory Kirk, Erin D Bigler, Katherine Bowen, Nicole O'Brien, Bedda Rosario, Sue R Beers, Paul Rathouz and 2 more

Open access · greenAbstract readClinical TrialMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of neurotrauma, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 1 country.

Peter FerrazzanoWaisman Center, University of Wisconsin, Madison, Wisconsin, USA.
Benjamin YeskeWaisman Center, University of Wisconsin, Madison, Wisconsin, USA.
Jeanette MumfordCenter for Healthy Minds, University of Wisconsin, Madison, Wisconsin, USA.
Gregory KirkWaisman Center, University of Wisconsin, Madison, Wisconsin, USA.
Erin D BiglerDepartment of Psychology and Neuroscience Center, Brigham Young University, Provo, Utah, USA.
Katherine BowenSeattle Children's Hospital, Seattle, Washington, USA.
Nicole O'BrienDepartment of Pediatrics, Division of Critical Care Medicine Nationwide Children's Hospital, The Ohio State University, Columbus, Ohio, USA.
Bedda RosarioDepartment of Epidemiology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Sue R BeersDepartment of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Paul RathouzDepartment of Population Health, University of Texas at Austin Dell Medical School, Austin, Texas, USA.
Michael J BellDepartment of Pediatrics, Children's National Medical Center, Washington, DC, USA.
Andrew L AlexanderWaisman Center, University of Wisconsin, Madison, Wisconsin, USA.
University of Wisconsin–Madison · USUniversity of Pittsburgh · USBrigham Young University · USChildren's National · USNationwide Children's Hospital · USSeattle Children's Hospital · USThe University of Texas at Austin · US

Funding

Multiple Medical Therapies for Pediatric TBI; Comparative Effectiveness ApproachU01NS081041 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BELL, MICHAEL J, WISNIEWSKI, STEPHEN R · 2013 to 2017
$15.9M
Waisman Intellectual and Developmental Disabilities Research Center Down Syndrome RegistryU54HD090256 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI MESSING, ALBEE · 2016 to 2020
$6.0M
MRI markers of functional outcome after severe pediatric TBIR01NS092870 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI ALEXANDER, ANDREW L, FERRAZZANO, PETER A · 2016 to 2019
$2.2M
Age-dependent microglial responses in hypoxia-ischemiaK08NS078113 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI FERRAZZANO, PETER A · 2013 to 2017
$967k
NICHD NIH HHS U54 HD090256NINDS NIH HHS K08 NS078113NINDS NIH HHS R01 NS092870NINDS NIH HHS U01 NS081041
6 · The paper itself

Abstract

Adolescent traumatic brain injury (TBI) is a major public health concern, resulting in >35,000 hospitalizations in the United States each year. Although neuroimaging is a primary diagnostic tool in the clinical assessment of TBI, our understanding of how specific neuroimaging findings relate to outcome remains limited. Our study aims to identify imaging biomarkers of long-term neurocognitive outcome after severe adolescent TBI. Twenty-four adolescents with severe TBI (Glasgow Coma Scale ≤8) enrolled in the ADAPT (Approaches and Decisions after Pediatric TBI) study were recruited for magnetic resonance imaging (MRI) scanning 1-2 years post-injury at 13 participating sites. Subjects underwent outcome assessments ∼1-year post-injury, including the Wechsler Abbreviated Scale of Intelligence (IQ) and the Pediatric Glasgow Outcome Scale-Extended (GOSE-Peds). A typically developing control cohort of 38 age-matched adolescents also underwent scanning and neurocognitive assessment. Brain-image segmentation was performed on T

Indexed as

Patient AcuityAdolescentBrain Injuries, TraumaticCerebral VentriclesChildCorpus CallosumFemaleHumansMagnetic Resonance ImagingMaleOrgan SizeRecovery of FunctionTreatment Outcomecognitive functioncorpus callosumMRIsevere adolescent brain injurytraumatic brain injuryventricle-to-brain ratio

Identifiers

PMID33487126
PMCPMC8219192
OpenAlexW3124244180

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.