ArticlePhilosophical transactions of the Royal Society of London. Series B, Biological sciences2021
From environmental sensing to developmental control: cognitive evolution in dictyostelid social amoebas.
Article in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 38 citations in OpenAlex.
- Early cAMP signaling orchestrates single-cell synchronicity throughout Dictyostelium development.Communications biology · 2026Article
- The overlooked amoebae of an agroecosystem of black soil land in China: five new species of dictyostelids.Applied and environmental microbiology · 2025Article
- On the prospects of basal cognition research becoming fully evolutionary: promising avenues and cautionary notes.History and philosophy of the life sciences · 2025Article
- Limitations of 18S rDNA Sequence in Species-Level Classification of Dictyostelids.Microorganisms · 2025Article
- Entropy and Cross-Level Orderliness in Light of the Interconnection between the Neural System and Consciousness.Entropy (Basel, Switzerland) · 2023Review
- Co-option of stress mechanisms in the origin of evolutionary novelties.Evolution; international journal of organic evolution · 2022Article
- Evolution of Multicellularity.Genes · 2021Article
- The Consequences of Budding versus Binary Fission on Adaptation and Aging in Primitive Multicellularity.Genes · 2021Article
- Reframing cognition: getting down to biological basics.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dictyostelid social amoebas respond to starvation by self-organizing into multicellular slugs that migrate towards light to construct spore-bearing structures. These behaviours depend on excitable networks that enable amoebas to produce propagating waves of the chemoattractant cAMP, and to respond by directional movement. cAMP additionally regulates cell differentiation throughout development, with differentiation and cell movement being coordinated by interaction of the stalk inducer c-di-GMP with the adenylate cyclase that generates cAMP oscillations. Evolutionary studies indicate how the manifold roles of cAMP in multicellular development evolved from a role as intermediate for starvation-induced encystation in the unicellular ancestor. A merger of this stress response with the chemotaxis excitable networks yielded the developmental complexity and cognitive capabilities of extant Dictyostelia. This article is part of the theme issue 'Basal cognition: conceptual tools and the view from the single cell'.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.