ArticleGlobal spine journal2022
Association Between Vitamin A Intake and Disease Severity in Early-Onset Heterotopic Ossification of the Posterior Longitudinal Ligament of the Spine.
Article in Global spine journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 19 citations in OpenAlex.
- The relationship between OPLL and metabolic disorders.Bone research · 2025Review
- Heterotopic ossification: Current developments and emerging potential therapies.Chinese medical journal · 2025Review
- A synthetic retinoic acid receptor γ antagonist (7C)-loaded nanoparticle enhances bone morphogenetic protein-induced bone regeneration in a rat spinal fusion model.The spine journal : official journal of the North American Spine Society · 2024Article
- Aggravation of Ossified Ligamentum Flavum Lesion Is Associated With the Degree of Obesity.Global spine journal · 2023Article
- Review of Basic Research about Ossification of the Spinal Ligaments Focusing on Animal Models.Journal of clinical medicine · 2023Review
- Lumbar ossification of the ligamentum flavum reflects a strong ossification tendency of the entire spinal ligament.Scientific reports · 2023Article
- Association between obesity and ossification of spinal ligaments in 622 asymptomatic subjects: a cross-sectional study.Journal of bone and mineral metabolism · 2022Article
- High Body Mass Index Is Associated with an Increased Risk of the Onset and Severity of Ossification of Spinal Ligaments.Frontiers in surgery · 2022Article
- Exosomes for gene therapy effectively inhibit the endothelial-mesenchymal transition in mouse aortic endothelial cells.BMC musculoskeletal disorders · 2021Article
- Close association between non-alcoholic fatty liver disease and ossification of the posterior longitudinal ligament of the spine.Scientific reports · 2021Article
- Visceral Fat and Ossification of the Posterior Longitudinal Ligament: Insights From a Japanese Cohort.JB & JS open accessArticle
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Authors and funding
17 authors at 10 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
STUDY
designA sex- and age-matched case-control study and a cross-sectional study.
objectiveIn our previous study, patients with early-onset (<50 years of age) ossification of the posterior longitudinal ligament (OPLL) had distinct features such as morbid obesity, a high prevalence of lifestyle-related diseases, and diffuse ossified lesions mainly affecting the thoracic spine. Our goals were to determine whether early-onset OPLL patients have unbalanced dietary habits and to identify nutritional factors associated with OPLL exacerbation.
methodsIn Study 1, the simple brief-type self-administered diet history questionnaire (BDHQ) was used to compare nutrient intake levels of early-onset OPLL patients (n = 13) with those of sex- and age-matched non-OPLL controls (n = 39) or with those of common OPLL (onset age ≥ 50 years, n = 62). In Study 2, serological validation was conducted for thoracic OPLL patients (n = 77) and non-OPLL controls (n = 101) in a nationwide multicenter study in Japan.
resultsThe BDHQ showed that the early-onset OPLL patients had significantly lower intakes of vitamins A and B6 than non-OPLL controls. These results were validated by lower serum vitamins A and B6 levels in the early-onset thoracic OPLL patients. The severity of OPLL negatively correlated with serum vitamin A levels in male early-onset OPLL patients. The multiple regression analysis revealed that the severity of thoracic OPLL had an association with onset age and serum vitamin A level.
conclusionsVitamin A deficiency resulting from unbalanced dietary habits is associated with exacerbation of male early-onset OPLL.
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