ArticleAIDS care2021
Poor quality of life and incomplete self-reported adherence predict second-line ART virological failure in resource-limited settings.
Article in AIDS care, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Food Insecurity Among Sexual and Gender Diverse Persons in Brazil: Impact of COVID-19 Pandemic and Associations with Antiretroviral Nonadherence Among People Living with HIV.AIDS and behavior · 2026Article
- Validation of the Perceived Barriers to Antiretroviral Therapy Adherence (PEDIA) Scale Among Gay, Bisexual, and Other Men Who Have Sex With Men and Transgender and Nonbinary Persons: Cross-Sectional Study.JMIR public health and surveillance · 2025Article
- Health-related quality of life and hypertension in people with HIV on long-term antiretroviral therapy in Uganda.PloS one · 2024Article
- Article
- A Review of Chronic Comorbidities in People Living With HIV in Peru.Journal of the International Association of Providers of AIDS CareReview
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Authors and funding
11 authors.
Funding
Abstract
We evaluated health-related quality of life (QoL) and self-reported incomplete adherence as predictors of early second-line antiretroviral (ART) virological failure (VF). ACTG A5273 study participants completed the ACTG SF-21 measure which has 8 QoL domains. We used exact logistic regression to assess the association of QoL at baseline and week 4 with early VF adjusted for self-reported adherence. Of 500 individuals (51% women, median age 39 years) in this analysis, 79% and 75% self-reported complete adherence (no missing doses in the past month) at weeks 4 and 24, respectively. Early VF was experienced by 7% and more common among those who self-reported incomplete adherence. Participants with low week 4 QoL scores had higher rates of early VF than participants with high scores. After adjusting for self-reported adherence at week 4, VL and CD4 at baseline, cognitive functioning, pain and mental health domains were significantly associated with subsequent early VF. In this post-hoc analysis, poorer QoL adds to self-reported incomplete adherence after 4 weeks of second-line ART in predicting VF at week 24. Evaluation is needed to assess whether individuals with poorer QoL might be targeted for greater support to reduce risk of VF.
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