ArticleDiabetes/metabolism research and reviews2021
A longitudinal study of thyroid markers during pregnancy and the risk of gestational diabetes mellitus and post-partum glucose metabolism.
Article in Diabetes/metabolism research and reviews, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Pooled it
- Thyroid markers in early to mid-pregnancy and risk of gestational diabetes: a longitudinal retrospective cohort study.Frontiers in endocrinology · 2026Article
- Article
- Maternal Thyroid Hormone Evaluation in Women With Gestational Diabetes Mellitus in the Second Trimester.Cureus · 2025Article
- Free thyroxine modifying the association of serum ferritin with gestational diabetes risk: A retrospective cohort study.Nutrition journal · 2025Article
- Pregnancy-associated thyroid disorders: the role of genetic, epigenetic, and oxidative stress factors.Reviews in endocrine & metabolic disorders · 2025Review
- Free triiodothyronine and risk of gestational diabetes mellitus: an observational study and Mendelian randomization analysis.Nutrition & metabolism · 2025Article
- Predictive Utility of Biochemical Markers for the Diagnosis and Prognosis of Gestational Diabetes Mellitus.International journal of molecular sciences · 2024Review
- Article
- The impact of gut microbiota on autoimmune thyroiditis and relationship with pregnancy outcomes: a review.Frontiers in cellular and infection microbiology · 2024Review
- An Evaluation of the Second Trimester Thyroid Function Test in Gestational Diabetes Mellitus: A Case-Control Study.Cureus · 2023Article
- Pregnancy outcomes and neonatal thyroid function in women with thyroid cancer: a retrospective study.BMC pregnancy and childbirth · 2023Article
- Article
- Thyroid autoimmunity and adverse pregnancy outcomes: A multiple center retrospective study.Frontiers in endocrinology · 2023Article
- Higher Thyroid fT3-to-fT4 Ratio Is Associated with Gestational Diabetes Mellitus and Adverse Pregnancy Outcomes.Journal of clinical medicine · 2022Article
- sCD40L Is Increased and Associated with the Risk of Gestational Diabetes Mellitus in Pregnant Women with Isolated TPOAb Positivity.International journal of endocrinology · 2022Article
- A Novel Nomogram for Predicting Gestational Diabetes Mellitus During Early Pregnancy.Frontiers in endocrinology · 2021Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsTo determine the relationship between thyroid markers during pregnancy and gestational diabetes mellitus (GDM) or post-partum glucose metabolism. MATERIALS AND
methodsBased on pregnancy 75-g oral glucose tolerance test (OGTT) results, 1467 subjects were grouped into normal glucose tolerance (NGTp; n = 768) and GDM (n = 699) groups. Furthermore, based on post-partum 75-g OGTT results, 286 GDM subjects, screened for glucose metabolism after delivery, were grouped into NGTd (n = 241) and abnormal glucose tolerance (AGT; n = 45) groups.
resultsMaternal age, family history of diabetes, acanthosis nigricans, previous adverse pregnancy outcomes and caesarean section incidence, and thyroid positive antibody rates were higher in the GDM group than in the NGTp group. In the first trimester, free triiodothyronine (FT3), thyroid peroxidase antibody (TPOAb) and thyroglobulin antibody (TgAb) levels were higher in the GDM group than in the NGTp group. In the second trimester, free thyroxine (FT4) levels were lower and TPOAb and TgAb levels were higher in the GDM group than in the NGTp group. After adjusting for confounding factors, FT3, TPOAb and TgAb (first trimester), and FT4, TPOAb and TgAb (second trimester) were risk factors for GDM. TPOAb and TgAb levels were higher in the AGT group than in the NGTd group and were potential predictors of abnormal post-partum glucose tolerance.
conclusionsGDM risk significantly increased with increased FT3 (first trimester), TPOAb and TgAb (first and second trimesters) or with decreased FT4 (second trimester). Presence of thyroid antibodies predicted post-partum glucose abnormalities in subjects with GDM.
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