Evidence map›Paper›PMID 33486773›Full record

ArticleHepatology (Baltimore, Md.)2021

Administrative Coding in Electronic Health Care Record-Based Research of NAFLD: An Expert Panel Consensus Statement.

Hannes Hagström, Leon A Adams, Alina M Allen, Christopher D Byrne, Yoosoo Chang, Henning Grønbaek, Mona Ismail, Peter Jepsen, Fasiha Kanwal, Jennifer Kramer and 16 more

Open access · hybridAbstract readConsensus Statement
In one paragraph

Article in Hepatology (Baltimore, Md.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 130 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
130citing papers in PubMed, 3 pooled it
14.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

130 citing papers in PubMed, 3 syntheses or guidelines pooled it, 237 citations in OpenAlex.

  1. Clinical Outcomes and Non-Invasive Testing in Metabolic Dysfunction-Associated Steatohepatitis With Cirrhosis: A Systematic Review.Liver international : official journal of the International Association for the Study of the Liver · 2026
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  17. Implications of Expanded Advanced Fibrosis Screening Strategies for Metabolic Dysfunction-Associated Steatotic Liver Disease in Primary Care.Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists · 2026
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70 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors at 19 institutions in 13 countries.

Hannes HagströmDivision of Hepatology, Department of Upper GI, Karolinska University Hospital, Stockholm, Sweden.ORCID 0000-0002-8474-1759
Leon A AdamsMedical School, University of Western Australia, Perth, WA, Australia.ORCID 0000-0002-3968-7909
Alina M AllenDivision of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN.ORCID 0000-0002-8393-8410
Christopher D ByrneNutrition and Metabolism, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.ORCID 0000-0001-6322-7753
Yoosoo ChangCenter for Cohort Studies, Total Healthcare Center, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
Henning GrønbaekDepartment of Hepatology and Gastroenterology, Aarhus University Hospital, Aarhus, Denmark.ORCID 0000-0001-8998-7910
Mona IsmailDivision of Gastroenterology, Department of Internal Medicine, King Fahad Hospital of the University, Al-Khobar, Saudi Arabia.
Peter JepsenDepartment of Hepatology and Gastroenterology, Aarhus University Hospital, Aarhus, Denmark.
Fasiha KanwalBaylor College of Medicine and Michael E. DeBakey VA Medical Center, Houston, TX.
Jennifer KramerBaylor College of Medicine and Michael E. DeBakey VA Medical Center, Houston, TX.ORCID 0000-0003-2953-4949
Jeffrey V LazarusBarcelona Institute for Global Health (ISGlobal), Hospital Clínic, University of Barcelona, Barcelona, Spain.ORCID 0000-0001-9618-2299
Michelle T LongDepartment of Medicine, Section of Gastroenterology, Boston University School of Medicine, Boston, MA.ORCID 0000-0001-6131-3981
Rohit LoombaNAFLD Research Center, Division of Gastroenterology and Epidemiology, University of California at San Diego, La Jolla, CA.
Philip N NewsomeNational Institute for Health Research Biomedical Research Centre at University Hospitals Birmingham NHS Foundation Trust, University of Birmingham, Birmingham, United Kingdom.ORCID 0000-0001-6085-3652
Ian A RoweLeeds Institute for Medical Research, University of Leeds, Leeds, United Kingdom.ORCID 0000-0003-1288-0749
Seungho RyuCenter for Cohort Studies, Total Healthcare Center, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
Jörn M SchattenbergMetabolic Liver Research Program, I. Department of Medicine, University Medical Center of the Johannes Gutenberg-University, Mainz, Germany.ORCID 0000-0002-4224-4703
Marina SerperDivision of Gastroenterology and Hepatology, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.
Nick SheronFoundation for Liver Research, London, United Kingdom.
Tracey G SimonDivision of Gastroenterology and Hepatology, Massachusetts General Hospital, Boston, MA.ORCID 0000-0003-0610-5287
Elliot B TapperDivision of Gastroenterology and Hepatology, University of Michigan, Ann Arbor, MI.ORCID 0000-0002-0839-1515
Sarah WildUsher Institute, University of Edinburgh, Edinburgh, United Kingdom.
Vincent Wai-Sun WongDepartment of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong.ORCID 0000-0003-2215-9410
Yusuf YilmazLiver Research Unit, Institute of Gastroenterology, Marmara University, Istanbul, Turkey.
Shira Zelber-SagiSchool of Public Health, University of Haifa, Haifa, Israel.
Fredrik ÅbergTransplantation and Liver Surgery Clinic, Helsinki University Hospital, Helsinki, Finland.ORCID 0000-0002-3833-0705
Karolinska Institutet · SEKarolinska University Hospital · SEAarhus University Hospital · DKMichael E. DeBakey VA Medical Center · USBarcelona Institute for Global Health · ESBoston University · USChinese University of Hong Kong · HKHarvard University · USJohannes Gutenberg University Mainz · DEKangbuk Samsung Hospital · KRKing Fahd Hospital of the University · SAMayo Clinic in Arizona · USSouthampton General Hospital · GBThe University of Western Australia · AUUniversity Hospitals Birmingham NHS Foundation Trust · GBUniversity of California San Diego · USUniversity of Haifa · ILUniversity of Leeds · GBUniversity of Michigan · US

Funding

UC San Diego Clinical and Translational Research InstituteUL1TR001442 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FIRESTEIN, GARY S, HOGARTH, MICHAEL · 2015 to 2024
$88.3M
Yeast Genetics and Stress Response Genes-BiomedicalP42ES010337 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI TUKEY, ROBERT H · 2000 to 2022
$69.8M
Pediatric Trials in Non-Alcoholic Steatohepatitis (NASH)U01DK061734 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ROHIT LOOMBA · 2002 to 2026
$24.4M
Tissue-specific roles of FXR in CVD and NASHP01HL147835 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GLASS, CHRISTOPHER K · 2020 to 2024
$12.2M
San Diego Digestive Diseases Research CenterP30DK120515 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LARS ECKMANN, Bernd G. Schnabl · 2019 to 2026
$10.8M
HIV MASLD Clinical Research Network (HCRN)R01DK121378 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI NAGA P CHALASANI, ROHIT LOOMBA · 2020 to 2026
$8.7M
QUS Technology for Diagnosis and Grading of Hepatic Steatosis in NAFLDR01DK106419 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LOOMBA, ROHIT, SIRLIN, CLAUDE B · 2015 to 2019
$3.4M
Non-invasive screening of diabetics for advanced fibrosis due to NAFLDR01DK124318 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LOOMBA, ROHIT · 2020 to 2022
$1.7M
Aspirin and Novel Lipid Mediators in Nonalcoholic Fatty Liver DiseaseK23DK122104 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI SIMON, TRACEY · 2019 to 2023
$1.1M
Identifying clinical and genetic correlates of hepatic fibrosis from fatty liver disease in the communityK23DK113252 · NIDDK · BOSTON MEDICAL CENTER · PI LONG, MICHELLE T · 2018 to 2022
$944k
Noninvasive detection of NASH by magnetic resonance elastography (MRE)K23DK115594 · NIDDK · MAYO CLINIC ROCHESTER · PI ALLEN, ALINA M · 2018 to 2022
$846k
NCATS NIH HHS UL1 TR001442NHLBI NIH HHS P01 HL147835NIDDK NIH HHS K23 DK113252NIDDK NIH HHS K23 DK115594NIDDK NIH HHS K23 DK122104NIDDK NIH HHS L30 DK106778NIDDK NIH HHS P30 DK120515NIDDK NIH HHS R01 DK106419NIDDK NIH HHS R01 DK121378NIDDK NIH HHS R01 DK124318NIDDK NIH HHS U01 DK061734NIEHS NIH HHS P42 ES010337
6 · The paper itself

Abstract

BACKGROUND AND

aimsElectronic health record (EHR)-based research allows the capture of large amounts of data, which is necessary in NAFLD, where the risk of clinical liver outcomes is generally low. The lack of consensus on which International Classification of Diseases (ICD) codes should be used as exposures and outcomes limits comparability and generalizability of results across studies. We aimed to establish consensus among a panel of experts on ICD codes that could become the reference standard and provide guidance around common methodological issues. APPROACH AND

resultsResearchers with an interest in EHR-based NAFLD research were invited to collectively define which administrative codes are most appropriate for documenting exposures and outcomes. We used a modified Delphi approach to reach consensus on several commonly encountered methodological challenges in the field. After two rounds of revision, a high level of agreement (>67%) was reached on all items considered. Full consensus was achieved on a comprehensive list of administrative codes to be considered for inclusion and exclusion criteria in defining exposures and outcomes in EHR-based NAFLD research. We also provide suggestions on how to approach commonly encountered methodological issues and identify areas for future research.

conclusionsThis expert panel consensus statement can help harmonize and improve generalizability of EHR-based NAFLD research.

Indexed as

ConsensusBiomedical ResearchClinical CodingElectronic Health RecordsHumansNon-alcoholic Fatty Liver DiseaseReference Standards

Identifiers

PMID33486773
PMCPMC8515502
OpenAlexW3126086196

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.