Evidence map›Paper›PMID 33486744›Full record

ArticleHepatology international2021

GATA6 modulates the ductular reaction to bile duct ligation.

Marjut Pihlajoki, Tea Soini, Rebecca B Cochran, Emmi Liljeström, Jiansheng Huang, David A Rudnick, Dennis J Dietzen, Antti Kyrönlahti, Mikko P Pakarinen, Markku Heikinheimo and 1 more

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Article in Hepatology international, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Amelioration of Liver Fibrosis via In Situ Hepatic Stellate Cell Conversion Through Co-Inhibition of TGF-β and GSK-3 Signalling.Liver international : official journal of the International Association for the Study of the Liver · 2025
    Article
  2. Article
  3. An animal model recapitulates human hepatic diseases associated withProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  4. Role of Immune Cells in Biliary Repair.Frontiers in immunology · 2022
    Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Marjut Pihlajoki *Pediatric Research Center, Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Tea Soini *Pediatric Research Center, Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Rebecca B CochranDepartment of Pediatrics, St. Louis Children's Hospital, Washington University School of Medicine, St. Louis, MO, USA.
Emmi LiljeströmPediatric Research Center, Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Jiansheng HuangDepartment of Pediatrics, St. Louis Children's Hospital, Washington University School of Medicine, St. Louis, MO, USA.
David A RudnickDepartment of Pediatrics, St. Louis Children's Hospital, Washington University School of Medicine, St. Louis, MO, USA.
Dennis J DietzenDepartment of Pediatrics, St. Louis Children's Hospital, Washington University School of Medicine, St. Louis, MO, USA.
Antti KyrönlahtiPediatric Research Center, Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Mikko P PakarinenPediatric Research Center, Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Markku HeikinheimoPediatric Research Center, Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
David B WilsonDepartment of Pediatrics, St. Louis Children's Hospital, Washington University School of Medicine, St. Louis, MO, USA. wilson_d@wustl.edu.ORCID http://orcid.org/0000-0002-1826-7745
St. Louis Children's Hospital · USUniversity of Helsinki · FI

Funding

NIH HHS DK020579NIH HHS DK52574U.S. Department of Defense OC150105 (W81XWH-16-1-0188)
6 · The paper itself

Abstract

backgroundGATA6, a transcription factor expressed in cholangiocytes, has been implicated in the response to liver injury. In biliary atresia, a disease characterized by extrahepatic bile duct obstruction, liver expression of GATA6 increases with pathological bile duct expansion and decreases after successful Kasai portoenterostomy. The aim of this study was to garner genetic evidence that GATA6 is involved in ductular formation/expansion.

methodsThe murine Gata6 gene was conditionally deleted using Alb-cre, a transgene expressed in hepatoblasts (the precursors of hepatocytes and cholangiocytes) and mature hepatocytes. Bile duct ligation (BDL) was used to model biliary obstruction.

resultsAlb-Cre;Gata6

conclusionsGATA6 orchestrates intrahepatic biliary remodeling and mitigates liver injury following extrahepatic bile duct obstruction.

Indexed as

Bile DuctsAnimalsBiliary AtresiaCholestasisGATA6 Transcription FactorHepatocytesLigationLiverMiceGata6 protein, mouseGATA6 Transcription FactorBiliary atresiaBiliary obstructionCholangiocyteGATA factorGene expressionHepatocyteLiverMousePartial hepatectomyTranscription factor

Identifiers

PMID33486744
OpenAlexW3124891337

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.