Evidence map›Paper›PMID 33486668›Full record

Observational studySleep & breathing = Schlaf & Atmung2021

CPAP treatment in REM-related obstructive sleep apnea: a distinct clinical phenotype of sleep disordered breathing.

Xiao Ya Hu, Jin-Gun Cho, Rita Perri, Terence Ting, Khaled Al Oweidat, Stephen Lambert, John Wheatley

Abstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in Sleep & breathing = Schlaf & Atmung, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. REM sleep obstructive sleep apnoea.European respiratory review : an official journal of the European Respiratory Society · 2024
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Xiao Ya HuDepartment of Respiratory and Sleep Medicine, Westmead Hospital, Westmead, NSW, Australia.
Jin-Gun ChoDepartment of Respiratory and Sleep Medicine, Westmead Hospital, Westmead, NSW, Australia.
Rita PerriLudwig Engel Centre for Respiratory Research, Westmead Institute for Medical Research, Westmead, NSW, Australia.
Terence TingDepartment of Respiratory and Sleep Medicine, Westmead Hospital, Westmead, NSW, Australia.
Khaled Al OweidatDepartment of Respiratory and Sleep Medicine, Westmead Hospital, Westmead, NSW, Australia.
Stephen LambertDepartment of Respiratory and Sleep Medicine, Westmead Hospital, Westmead, NSW, Australia.
John WheatleyDepartment of Respiratory and Sleep Medicine, Westmead Hospital, Westmead, NSW, Australia. john.wheatley@health.nsw.gov.au.ORCID 0000-0002-1605-8843
The University of Sydney · AUWestmead Hospital · AUWestmead Institute for Medical Research · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeREM-related obstructive sleep apnea (REM-OSA), as defined using revised apnea-hypopnea index (AHI) criteria, might represent a specific OSA phenotype. However, there is a lack of data on outcomes of treatment in this population. This study evaluated the effects of CPAP treatment over 12 months on clinical outcomes for patients with the polysomnography phenotype of REM-OSA.

methodsWe conducted a prospective observational study with the following inclusion criteria: subjective sleepiness and diagnostic polysomnography demonstrating AHI

resultsTwenty participants completed a minimum of 1 month of CPAP treatment and were included for analysis. During the trial, 8 participants discontinued CPAP (4 before 3 months, 1 before 6 months, 3 before 12 months), and 19 participants completed 12 months of treatment. Baseline ESS was elevated at 12.6 units. Average CPAP usage for all 27 participants over 12 months was 2.9 ± 2.4 h. There was a significant decrease in ESS and increase in FOSQ at all time points, and the decrease in ESS was only seen in the CPAP-adherent subgroup. Decreases in DASS-21 and PVT-RT were not sustained.

conclusionsCPAP treatment in sleepy patients with moderate to severe REM-OSA is associated with reduced sleepiness and improved quality of life.

trial registrationThe trial was registered in the Australian New Zealand Clinical Trials Registry: ACTRN12620000576921, 18/05/2020 (retrospectively registered).

Indexed as

AdultContinuous Positive Airway PressureFemaleHumansMaleMiddle AgedOutcome Assessment, Health CarePhenotypeProspective StudiesSleep Apnea, ObstructiveSleep, REMContinuous positive airway pressureHealth-related quality of lifeObstructive sleep apneaPatient adherenceREM sleepSleepiness

Identifiers

PMID33486668
OpenAlexW3125950126

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.