Evidence map›Paper›PMID 33486601›Full record

ArticleAAPS PharmSciTech2021

New PTX-HS15/T80 Mixed Micelles: Cytotoxicity, Pharmacokinetics and Tissue Distribution.

Baoyu Liu, Wei Gao, Hui Wu, Hong Liu, Hongchun Pan

Abstract read
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In one paragraph

Article in AAPS PharmSciTech, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Baoyu LiuCollege of Pharmaceutical Sciences, Southwest University, Chongqing, China.
Wei GaoQingdao Eye Hospital of Shandong First Medical University, Qingdao, Shandong, China.
Hui WuCollege of Pharmaceutical Sciences, Southwest University, Chongqing, China.
Hong LiuCollege of Pharmaceutical Sciences, Southwest University, Chongqing, China. lhphch@126.com.
Hongchun PanCollege of Pharmaceutical Sciences, Southwest University, Chongqing, China. panhongchun216@126.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Compared with single micelle, the new PTX-HS15/T80 mixed micelle system (PTX-HS15/T80 MMs) had achieved better results in solubilization, stability, and sensitization before. Therefore, we intend to further verify the potential advantages of the mixed micelle delivery system through in vitro cytotoxicity test and animal test to understand the anticancer effect and in vivo pharmaceutical behavior of the system. In vitro cytotoxicity test showed that the new PTX-HS15/T80 MMs had a stronger ability to inhibit the proliferation of cancer cells. The results of in vivo pharmacokinetics showed that the micelle had shorter half-life, higher clearance rate, and lower blood concentration and had good blood clearance characteristics. The results of in vivo tissue distribution showed that, compared with the single micelle Taxol

Indexed as

Drug Delivery SystemsMicellesAnimalsAntineoplastic Agents, PhytogenicCell Line, TumorFemaleMalePaclitaxelPolyethylene GlycolsPolysorbatesRatsRats, Sprague-DawleyStearic AcidsTissue DistributionAntineoplastic Agents, PhytogenicMicellesPaclitaxelPolyethylene GlycolsPolysorbatesSolutol HS 15Stearic Acidscytotoxicmixed micellespaclitaxelpharmacokineticstissue distribution

Identifiers

PMID33486601

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.