Evidence map›Paper›PMID 33486545›Full record

ArticleInflammation research : official journal of the European Histamine Research Society ... [et al.]2021

microRNA-155-3p attenuates intervertebral disc degeneration via inhibition of KDM3A and HIF1α.

Xianwei Zhou, Jitian Li, Junyan Teng, Yufeng Liu, Di Zhang, Linyun Liu, Wenming Zhang

Abstract read
PubMed Publisher
In one paragraph

Article in Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Xianwei ZhouSpine Surgery, Luoyang Orthopedic Hospital of Henan Province, No. 100 Yongping Road, Henan, 450000, Zhengzhou, China.
Jitian LiLaboratory of Bone Tumor, Luoyang Orthopedic Hospital of Henan Province, Henan, 450000, Zhengzhou, China.
Junyan TengDepartment of Osteoarthrosis and Health Management Center, Luoyang Orthopedic Hospital of Henan Province, Henan, 450000, Zhengzhou, China.
Yufeng LiuSpine Surgery, Luoyang Orthopedic Hospital of Henan Province, No. 100 Yongping Road, Henan, 450000, Zhengzhou, China.
Di ZhangSpine Surgery, Luoyang Orthopedic Hospital of Henan Province, No. 100 Yongping Road, Henan, 450000, Zhengzhou, China.
Linyun LiuDepartment of Osteoarthrosis and Health Management Center, Luoyang Orthopedic Hospital of Henan Province, Henan, 450000, Zhengzhou, China.
Wenming ZhangSpine Surgery, Luoyang Orthopedic Hospital of Henan Province, No. 100 Yongping Road, Henan, 450000, Zhengzhou, China. ZZZhangwenming1@163.com.ORCID http://orcid.org/0000-0003-2105-9805
Luoyang Orthopedic-Traumatological Hospital of Henan Province · CN

Funding

A research on personalized spinal three-dimensional printing intervertebral fusion cage in crenel lateral interbody fusion, office-level projects 2019ZY1031Key Scientific Research Projects on Chinese Medicine in Henan Province; Clinical application of personalized three-dimensional printing on external fixation of distal radius fractures, office-level projects 1723001A-4
6 · The paper itself

Abstract

objectiveIntervertebral disc degeneration (IDD) is a key element resulting in low back pain, but the mechanisms underlying IDD remain largely unknown. The purpose of the study was to investigate the influence of microRNA-155-3p (miR-155-3p) on proliferation and autophagy of nucleus pulposus (NP) cells in IDD with the involvement of hypoxia-inducible factor 1 α (HIF1α)/histone lysine demethylase 3A (KDM3A) axis.

methodsIDD NP tissues of patients with lumbar disc herniation and traumatic intervertebral disc NP tissues from patients with traumatic lumbar fracture were collected. Apoptosis in NP tissues was observed, and autophagy marker proteins in NP tissues were detected. NP cells in IDD were transfected with miR-155-3p mimic or KDM3A-siRNA to explore their roles in cell proliferation, autophagy and apoptosis. MiR-155-3p, KDM3A and HIF1α expression in NP tissues and cells were detected.

resultsDecreased miR-155-3p, and elevated HIF1α and KDM3A were presented in NP tissues and cells of IDD. Elevated miR-155-3p or silenced KDM3A promoted the proliferation and autophagy, and inhibited the apoptosis of NP cells of IDD. Moreover, elevated miR-155-3p decreased KDM3A and HIF1α expression, while silenced KDM3A decreased HIF1α expression in NP cells with IDD.

conclusionThe study concludes that up-regulated miR-155-3p or silenced KDM3A promotes the proliferation, autophagy, and restrains the apoptosis of NP cells of IDD via inhibition of HIF1α, which may be a promising approach for the treatment of IDD.

Indexed as

MicroRNAsAdolescentAdultApoptosisAutophagyCell ProliferationChildFemaleGene SilencingHumansHypoxia-Inducible Factor 1, alpha SubunitIntervertebral Disc DegenerationJumonji Domain-Containing Histone DemethylasesMaleMiddle AgedNucleus PulposusHIF1A protein, humanHypoxia-Inducible Factor 1, alpha SubunitJumonji Domain-Containing Histone DemethylasesKDM3A protein, humanMicroRNAsMIRN155 microRNA, humanApoptosisAutophagyHypoxia-inducible factor 1 αIntervertebral disc degenerationLysine demethylase 3AMicroRNA-155-3pNucleus pulposus cellsProliferation

Identifiers

PMID33486545
OpenAlexW3122360054

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.