Trial reportWorld journal of urology2021
A call for HoLEP: en-bloc vs. two-lobe vs. three-lobe.
Trial report in World journal of urology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 3 syntheses or guidelines pooled it, 56 citations in OpenAlex.
- Functional outcomes of one-, two- and three-lobe technique in anatomical endoscopic enucleation for benign prostatic obstruction: a systematic review and network-meta-analysis.World journal of urology · 2025Pooled it
- Peri- and post-operative outcomes, complications, and functional results amongst different modifications of endoscopic enucleation of the prostate (EEP): a systematic review and meta-analysis.World journal of urology · 2023Pooled it
- Incidence and risk factors for postoperative urinary incontinence after various prostate enucleation procedures: systemic review and meta-analysis of PubMed literature from 2000 to 2021.World journal of urology · 2022Pooled it
- A randomized controlled trial comparing en-bloc vs lobe-by-lobe HoLEP: surgical efficiency and early continence outcomes.Prostate cancer and prostatic diseases · 2026Trial
- Top-down holmium laser enucleation of the prostate (HoLEP) versus traditional HoLEP for the treatment of benign prostatic hyperplasia (BPH): 1-year outcomes of a randomized controlled trial.Prostate cancer and prostatic diseases · 2024Trial
- Randomized prospective trial of the severity of irritative symptoms after HoLEP vs ThuFLEP.World journal of urology · 2022Trial
- En-bloc and non-en-bloc techniques for thulium laser enucleation of the prostate: a comparative study of surgical outcomes.International urology and nephrology · 2026Article
- En-bloc HoLEP training and learning curve challenges: a multi-generational survey study.World journal of urology · 2026Article
- Holmium laser enucleation of prostate via perineal urethrostomy for the treatment of benign prostatic hyperplasia with mild long segment stenosis of the anterior urethra.Langenbeck's archives of surgery · 2026Review
- Holmium laser enucleation of the prostate (HoLEP): a narrative review of sexual side effects.Translational andrology and urology · 2026Review
- Comparison of three-lobe and en-bloc techniques during the holmium laser enucleation of the prostate learning curve: a prospective, multicenter, cohort study.Revista da Associacao Medica Brasileira (1992) · 2026Article
- "Double rings" En-bloc technique with early anatomical apical release in thuflep for the patients with large glands (≥ 80 mL): the outcomes from single center.BMC urology · 2025Article
- Endoscopic enucleation of the prostate in men aged 80 years and older. Outcomes from a global, large, and multicenter series using different energy sources and techniques.World journal of urology · 2025Article
- Safety and feasibility of En-bloc holmium laser enucleation for very large prostates (> 200 cc) with trainee involvement.BJUI compass · 2025Article
- Holmium laser enucleation of the prostate: Modified urethral mucosa pre-dissected technique versus traditional three-lobe technique-A retrospective study.Lasers in medical science · 2024Article
- Current era HOLEP with MOSES 2.0 technology compared to the gold standard TURP.World journal of urology · 2024Article
- Editorial comment on "Reevaluating 'Top-Down' HoLEP: the case for anterior fibromuscular stroma as a surgical landmark".Prostate cancer and prostatic diseases · 2024Article
- The long-term learning curve of holmium laser enucleation of the prostate (HoLEP) in the en-bloc technique: a single surgeon series of 500 consecutive cases.World journal of urology · 2024Article
- Refining surgical strategies in ThuLEP for BPH: a propensity score matched comparison of En-bloc, three lobes, and two lobes techniques.World journal of urology · 2024Article
- Real world propensity score matched analysis evaluating the influence of en-bloc vs. non en-bloc techniques, energy and instrumentation on enucleation outcomes for large and very large prostates.World journal of urology · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeHolmium Laser Enucleation of the Prostate (HoLEP) is widely accepted as standard laser enucleation technique for patients with benign prostate obstruction (BPO). Initially developed as a three-lobe enucleation technique, several modifications have been published. Comparison of the enucleation techniques is lacking. Therefor we aimed to compare outcomes of three enucleation techniques (en-bloc vs. two-lobe vs. three-lobe). MATERIAL AND
methodsWe prospectively collected data of 600 patients treated between 01/2017 and 12/2017 with HoLEP for BPO. Patients were randomised to either enbloc, two-lobe, or three-lobe enucleation, respectively. Data collection consisted of parameters on operation time, perioperative parameters, and functional outcomes. Univariate and multivariate analyses (ANOVA-test for continuous variables; Chi2-test for categorical variables) were performed regarding differences between the three enucleation techniques.
resultsPatient characteristics were not significantly different (all p > 0.05). Significant differences were observed with respect to overall operation time (en-bloc vs. two-lobe vs. three-lobe: 40.5 vs. 40.7 vs. 47.9, respectively; p < 0.001), speed (g/min.) (en-bloc vs. two-lobe vs. three-lobe, 1.82 vs. 1.76 vs. 1.67, respectively; p 0.006), and enucleation time (en-bloc vs. two-lobe vs. three-lobe: 31.7 vs. 32 vs. 37.7, respectively; p < 0.001). When solely comparing en-bloc vs. two-lobe enucleation, differences in terms of enucleation time, operation time, and speed were not significantly different (p 0.8, 0.9, and 0.2, respectively). Postoperative outcomes were not significantly different.
conclusionAll three HoLEP enucleation techniques show similar postoperative outcomes. However, enbloc and two-lobe enucleation are significantly faster with respect to enucleation, overall operation time, and speed compared to the three-lobe technique.
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