Evidence map›Paper›PMID 33486496›Full record

Trial reportRespiration; international review of thoracic diseases2021

Early Use of Corticosteroid May Prolong SARS-CoV-2 Shedding in Non-Intensive Care Unit Patients with COVID-19 Pneumonia: A Multicenter, Single-Blind, Randomized Control Trial.

Xiao Tang, Ying-Mei Feng, Ji-Xiang Ni, Jia-Ying Zhang, Li-Min Liu, Ke Hu, Xiu-Zhi Wu, Ji-Xian Zhang, Jun-Wen Chen, Jian-Chu Zhang and 10 more

Registry-linked trialOpen access · bronzeAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Respiration; international review of thoracic diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04273321 (Efficacy and Safety of Corticosteroids in COVID-19), which is not on this map. Cited by 83 papers, 18 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
83citing papers in PubMed, 18 pooled it
9.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04273321 nacompletednot on this map

Efficacy and Safety of Corticosteroids in COVID-19: A Prospective Randomized Controlled Trails

TypeinterventionalSponsorBeijing Chao Yang HospitalRan2020 to 2020Enrolled86ConditionsCOVID-19, Novel Coronavirus PneumoniaArmsMethylprednisolone
3 · Its place in the literature

Who cites it

83 citing papers in PubMed, 18 syntheses or guidelines pooled it, 145 citations in OpenAlex.

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  10. Use of steroids in COVID-19 patients: A meta-analysis.European journal of pharmacology · 2022
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  16. Systemic corticosteroids for the treatment of COVID-19.The Cochrane database of systematic reviews · 2021
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23 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 7 institutions in 1 country.

Xiao TangDepartment of Respiratory and Critical Care Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing Institute of Respiratory Medicine, Beijing, China, 121930193@qq.com.
Ying-Mei FengBeijing You-An Hospital, Capital Medical University, Beijing, China.
Ji-Xiang NiDepartment of Respiratory and Critical Care Medicine, Yi-Chang First People's Hospital, The People's Hospital of China Three Gorges University, Hubei Province, China.
Jia-Ying ZhangBeijing You-An Hospital, Capital Medical University, Beijing, China.
Li-Min LiuDepartment of Respiratory and Critical Care Medicine, Tianyou Hospital, Wuhan University of Science and Technology, Wuhan, China.
Ke HuDepartment of Respiratory and Critical Care Medicine, Renmin Hospital of Wuhan University, Wuhan, China.
Xiu-Zhi WuDepartment of Respiratory and Critical Care Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing Institute of Respiratory Medicine, Beijing, China.
Ji-Xian ZhangDepartment of Respiratory and Critical Care Medicine, Hubei Province Hospital of Integrated Chinese & Western Medicine, Wuhan, China.
Jun-Wen ChenDepartment of Respiratory and Critical Care Medicine, Xiang-Yang First people's Hospital, Hubei Province, China.
Jian-Chu ZhangDepartment of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Huazhong, China.
Jian SuDepartment of Respiratory and Critical Care Medicine, Yi-Chang First People's Hospital, The People's Hospital of China Three Gorges University, Hubei Province, China.
Yu-Lei LiDepartment of Respiratory and Critical Care Medicine, Tianyou Hospital, Wuhan University of Science and Technology, Wuhan, China.
Yang ZhaoDepartment of Respiratory and Critical Care Medicine, Renmin Hospital of Wuhan University, Wuhan, China.
Jiao XieDepartment of Respiratory and Critical Care Medicine, Hubei Province Hospital of Integrated Chinese & Western Medicine, Wuhan, China.
Zhou DingDepartment of Respiratory and Critical Care Medicine, Xiang-Yang First people's Hospital, Hubei Province, China.
Xin-Liang HeDepartment of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Huazhong, China.
Wen WangDepartment of Respiratory and Critical Care Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing Institute of Respiratory Medicine, Beijing, China.
Rong-Hua JinBeijing You-An Hospital, Capital Medical University, Beijing, China.
Huan-Zhong ShiDepartment of Respiratory and Critical Care Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing Institute of Respiratory Medicine, Beijing, China.
Bing SunDepartment of Respiratory and Critical Care Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing Institute of Respiratory Medicine, Beijing, China.
Capital Medical University · CNUnion Hospital · CNChina Three Gorges University · CNWuhan University · CNWuhan University of Science and Technology · CNXiang Yang No.1 People's Hospital · CNIntegrated Chinese Medicine (China) · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThere is still no clinical evidence available to support or to oppose corticosteroid treatment for coronavirus disease 2019 (COVID-19) pneumonia.

objectiveTo investigate the efficacy and safety of corticosteroid given to the hospitalized patients with COVID-19 pneumonia.

methodsThis was a prospective, multicenter, single-blind, randomized control trial. Adult patients with COVID-19 pneumonia who were admitted to the general ward were randomly assigned to either receive methylprednisolone or not for 7 days. The primary end point was the incidence of clinical deterioration 14 days after randomization.

resultsWe terminated this trial early because the number of patients with COVID-19 pneumonia in all the centers decreased in late March. Finally, a total of 86 COVID-19 patients underwent randomization. There was no difference of the incidence of clinical deterioration between the methylprednisolone group and control group (4.8 vs. 4.8%, p = 1.000). The duration of throat viral RNA detectability in the methylprednisolone group was 11 days (interquartile range, 6-16 days), which was significantly longer than that in the control group (8 days [2-12 days], p = 0.030). There were no significant differences between the 2 groups in other secondary outcomes. Mass cytometry discovered CD3+ T cells, CD8+ T cells, and NK cells in the methylprednisolone group which were significantly lower than those in the control group after randomization (p < 0.05).

conclusionsFrom this prematurely closed trial, we found that the short-term early use of corticosteroid could suppress the immune cells, which may prolong severe acute respiratory syndrome coronavirus 2 shedding in patients with COVID-19 pneumonia.

trial registrationClinicalTrials.gov, NCT04273321.

Indexed as

COVID-19 Drug TreatmentHospitalizationVirus SheddingAdultAgedAnti-Bacterial AgentsAntiviral AgentsCD3 ComplexCD8-Positive T-LymphocytesCOVID-19COVID-19 Nucleic Acid TestingDisease ProgressionEarly Medical InterventionExtracorporeal Membrane OxygenationFemaleGlucocorticoidsAnti-Bacterial AgentsAntiviral AgentsCD3 ComplexGlucocorticoidsMethylprednisoloneRNA, ViralCoronavirus disease 2019CorticosteroidOutcomePneumoniaVirus shedding

Identifiers

PMID33486496
PMCPMC7900459
OpenAlexW3122987078

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.