ArticleCortex; a journal devoted to the study of the nervous system and behavior2021
Development of lateral pulvinar resting state functional connectivity and its role in attention.
Article in Cortex; a journal devoted to the study of the nervous system and behavior, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Dynamic thalamocortical functional connectivity disruptions in Parkinson's disease with probable REM sleep behavior disorder.Scientific reports · 2026Article
- Advances in neuroimaging studies of thalamic abnormalities in children with attention deficit hyperactivity disorder.Psychoradiology · 2026Review
- Bilateral Angular Gyrus 810-nm Transcranial Near-Infrared Stimulation Reshapes Brain Network: Ameliorate Alzheimer's Disease Cognitive Deficits.BME frontiers · 2026Article
- Exploring connectivity and volume alterations in the Pulvinar's subnuclei: insights into the neuropathological role in obsessive-compulsive disorder (OCD).Psychological medicine · 2025Article
- Thalamic Volume Reduction in Cerebral Visual Impairment: Relationship to Visual Dysfunction.Journal of child neurology · 2025Article
- The Impact of Childhood Maltreatment on Central Pain Processing in Individuals With Psychosis.Bipolar disorders · 2025Article
- Reversal of hyperactive higher-order thalamus attenuates defensiveness in a mouse model of PTSD.Science advances · 2023Article
- Impairments to the multisensory integration brain regions during migraine chronification: correlation with the vestibular dysfunction.Frontiers in molecular neuroscience · 2023Article
- Abnormal developmental trends of functional connectivity in young children with infantile esotropia.Frontiers in neuroscience · 2022Article
- Sex-specific associations between traumatic experiences and resting-state functional connectivity in the Philadelphia Neurodevelopmental Cohort.JCPP advances · 2021Article
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Abstract
objectiveThe lateral pulvinar nucleus (LPN) has a well-established role in visual attention. Oscillatory activity of the LPN is critical for cortico-cortical communication within and among occipital and temporal visual processing regions. However, the functional development of the LPN and its role in attention deficits is not understood. This study examined the development of thalamic functional connectivity and its relation to attention abilities.
methodResting state functional Magnetic Resonance Imaging images from 950 participants (ages 8-21) in the Philadelphia Neurodevelopmental Cohort (PNC) were used to examine age effects. Follow-up General Linear Models were performed to examine brain-behavior effects with Attention Deficit Hyperactivity Disorder (ADHD) symptom ratings and D-prime scores from the Penn Continuous Performance Task, a behavioral measure of selective attention.
resultsLPN functional connectivity with ventral visual stream regions of the occipital and temporal cortices decreased with age, while LPN functional connectivity with the supplementary motor area increased with age. Weaker LPN connectivity in the inferior parietal lobule, supramarginal gyrus, posterior insula, and inferior frontal gyrus was associated with more ADHD symptoms; stronger pulvinar-cerebellar connectivity was also associated with more ADHD symptoms. Better D-prime scores were associated with greater connectivity between the pulvinar and superior parietal gyrus; better D-prime scores were associated with weaker pulvinar connectivity with striatal, middle temporal gyrus, and medial prefrontal cortex regions.
conclusionThese findings implicate the LPN in the development of the ventral visual processing stream between late childhood and early adulthood and suggest that LPN connectivity with higher order attention networks is important for attention abilities.
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