ArticleNeuroImage2021
Accrual of functional redundancy along the lifespan and its effects on cognition.
Article in NeuroImage, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 33 citations in OpenAlex.
- Perceived Complexity as Normalized, Integrated, Localized Shannon Entropy.Entropy (Basel, Switzerland) · 2026Article
- Association between processing speed and segregation/integration of large-scale functional networks in middle-aged and older people living with HIV.BMC neurology · 2026Article
- Functional redundancy of the posterior hippocampi is selectively disrupted in non-demented older adults withNeuroimage. Reports · 2025Article
- Noncoding RNA Terc-53 and hyaluronan receptor Hmmr regulate aging in mice.Protein & cell · 2025Article
- Investigating dynamic brain functional redundancy as a mechanism of cognitive reserve.Frontiers in aging neuroscience · 2025Article
- Impact of white matter hyperintensity volume on cognition among US Mexican American adults.Journal of the International Neuropsychological Society : JINS · 2024Article
- Choosing explanation over performance: Insights from machine learning-based prediction of human intelligence from brain connectivity.PNAS nexus · 2024Article
- Distributed associations among white matter hyperintensities and structural brain networks with fluid cognition in healthy aging.Cognitive, affective & behavioral neuroscience · 2024Article
- Age-related differences in network controllability are mitigated by redundancy in large-scale brain networks.Communications biology · 2024Article
- Small vessel disease and cognitive reserve oppositely modulate global network redundancy and cognitive function: A study in middle-to-old aged community participants.Human brain mapping · 2024Article
- The spatial distribution of coupling between tau and neurodegeneration in amyloid-β positive mild cognitive impairment.Neurobiology of aging · 2024Article
- Cognitive synaptopathy: synaptic and dendritic spine dysfunction in age-related cognitive disorders.Frontiers in aging neuroscience · 2024Review
- Brain topology underlying executive functions across the lifespan: focus on the default mode network.Frontiers in psychology · 2024Article
- Trade-offs among brain structural network characteristics across the cognitive decline process in cerebral small vessel disease.Frontiers in aging neuroscience · 2024Article
- Accumulation of network redundancy marks the early stage of Alzheimer's disease.Human brain mapping · 2023Article
- Identifying the regional substrates predictive of Alzheimer's disease progression through a convolutional neural network model and occlusion.Human brain mapping · 2022Article
- A robust core architecture of functional brain networks supports topological resilience and cognitive performance in middle- and old-aged adults.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Differential Role for Hippocampal Subfields in Alzheimer's Disease Progression Revealed with Deep Learning.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Subtyping of mild cognitive impairment using a deep learning model based on brain atrophy patterns.Cell reports. Medicine · 2021Article
- The association between hippocampal volume and memory in pathological aging is mediated by functional redundancy.Neurobiology of aging · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Despite the necessity to understand how the brain endures the initial stages of age-associated cognitive decline, no brain mechanism has been quantitatively specified to date. The brain may withstand the effects of cognitive aging through redundancy, a design feature in engineered and biological systems, which entails the presence of substitute elements to protect it against failure. Here, we investigated the relationship between functional network redundancy and age over the human lifespan and their interaction with cognition, analyzing resting-state functional MRI images and cognitive measures from 579 subjects. Network-wide redundancy was significantly associated with age, showing a stronger link with age than other major topological measures, presenting a pattern of accumulation followed by old-age decline. Critically, redundancy significantly mediated the association between age and executive function, with lower anti-correlation between age and cognition in subjects with high redundancy. The results suggest that functional redundancy accrues throughout the lifespan, mitigating the effects of age on cognition.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.