ArticleBMC musculoskeletal disorders2021
Mortality in older adults following a fragility fracture: real-world retrospective matched-cohort study in Ontario.
Article in BMC musculoskeletal disorders, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 2 of them syntheses that pooled it.
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Who cites it
57 citing papers in PubMed, 2 syntheses or guidelines pooled it, 101 citations in OpenAlex.
- Exercise Improves Upper-Limb Bone Health in Women: A Systematic Review and Meta-Analysis of Exercise Type and Intensity.Current osteoporosis reports · 2026Pooled it
- What are the Effects of Exercise on Trabecular Microarchitecture in Older Adults? A Systematic Review and Meta-analysis of HR-pQCT Studies.Calcified tissue international · 2023Pooled it
- Osteogenic, antiresorptive, and toxicological evaluation of alpha-mangostin in MC3T3-E1 cells and medaka fish.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2026Article
- Towards efficient osteoporosis screening: a simple and practical approach using OSTA and FRAX risk factors.Journal of bone and mineral metabolism · 2026Article
- Physical Resilience and Its Influencing Factors Among Older Patients with Fragility Fractures: A Cross-Sectional Study Based on Latent Profile Analysis.Healthcare (Basel, Switzerland) · 2026Article
- Serious adverse events and mortality among adults with non-surgically treated distal radius fractures- a nationwide population-based cohort study of 184,446 Danish patients.BMC musculoskeletal disorders · 2026Article
- An intelligent auxiliary diagnostic system for early osteoporosis screening using stacking ensemble learning.BMC medical informatics and decision making · 2026Article
- Mortality in patients over 65 with proximal humerus fractures: a systematic review of 414,379 shoulders with meta-analysis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026Review
- Too late, too often: missed opportunities in male bone health: a real-world portrait from a 14-year specialist referral experience.Journal of endocrinological investigation · 2026Observational
- Crohn's and bones: assessing bone microarchitecture using high-resolution peripheral quantitative computed tomography.JBMR plus · 2026Article
- Moderate-intensity exercise reduces osteoporotic fracture risk in older women: a dose-response analysis from a nationwide Korean cohort.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026Article
- GLP-2 alleviates postmenopausal osteoporosis by acting on osteoblasts through the PI3K/AKT/FOXO1 signalling pathway to downregulate FGF23 expression.Journal of orthopaedic surgery and research · 2026Article
- Orthogeriatric co-management of fragility fractures: a retrospective cohort study on one-year mortality and functional outcomes across fracture types.BMC geriatrics · 2025Article
- Excess short- and long-term mortality risk following any and hip fractures: a prospective matched cohort study using exposure density sampling.Scientific reports · 2025Article
- Conservative and Pharmacological Strategies for Preventing Osteoporotic Stress Fractures in Older Recreational Competitors.Healthcare (Basel, Switzerland) · 2025Review
- FactFinders for patient safety: Do epidural steroid injections increase the risk of fracture or lumbar surgical site infection?Interventional pain medicine · 2025Article
- Self-reported sleep disturbances are associated with osteoporosis: multivariable-adjusted and Mendelian randomization analyses in UK Biobank.JBMR plus · 2025Article
- Oral Administration of Hydrolyzed Egg Yolk Peptides With Low Molecular Weight Increased Bone Density by Regulating Bone Metabolism and Immune Responses.Journal of food science · 2025Article
- Bone Health, Fragility Fractures, and the Hand Surgeon.Journal of hand surgery global online · 2025Review
- Impact of social determinants on osteoporosis treatment and secondary fracture risk after primary fragility fractures.Archives of osteoporosis · 2025Article
Corrections and comments
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Authors and funding
11 authors at 7 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRecent studies are lacking reports on mortality after non-hip fractures in adults aged > 65.
methodsThis retrospective, matched-cohort study used de-identified health services data from the publicly funded healthcare system in Ontario, Canada, contained in the ICES Data Repository. Patients aged 66 years and older with an index fragility fracture occurring at any osteoporotic site between 2011 and 2015 were identified from acute hospital admissions, emergency and ambulatory care using International Classification of Diseases (ICD)-10 codes and data were analyzed until 2017. Thus, follow-up ranged from 2 years to 6 years. Patients were excluded if they presented with an index fracture occurring at a non-osteoporotic fracture site, their index fracture was associated with a trauma code, or they experienced a previous fracture within 5 years prior to their index fracture. This fracture cohort was matched 1:1 to controls within a non-fracture cohort by date, sex, age, geography and comorbidities. All-cause mortality risk was assessed.
resultsThe survival probability for up to 6 years post-fracture was significantly reduced for the fracture cohort vs matched non-fracture controls (p < 0.0001; n = 101,773 per cohort), with the sharpest decline occurring within the first-year post-fracture. Crude relative risk of mortality (95% confidence interval) within 1-year post-fracture was 2.47 (2.38-2.56) in women and 3.22 (3.06-3.40) in men. In the fracture vs non-fracture cohort, the absolute mortality risk within one year after a fragility fracture occurring at any site was 12.5% vs 5.1% in women and 19.5% vs 6.0% in men. The absolute mortality risk within one year after a fragility fracture occurring at a non-hip vs hip site was 9.4% vs 21.5% in women and 14.4% vs 32.3% in men.
conclusionsIn this real-world cohort aged > 65 years, a fragility fracture occurring at any site was associated with reduced survival for up to 6 years post-fracture. The greatest reduction in survival occurred within the first-year post-fracture, where mortality risk more than doubled and deaths were observed in 1 in 11 women and 1 in 7 men following a non-hip fracture and in 1 in 5 women and 1 in 3 men following a hip fracture.
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