ArticleMedical mycology2021
Filamentous growth is a general feature of Candida auris clinical isolates.
Article in Medical mycology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed, 47 citations in OpenAlex.
- Pathogenicity and virulence ofVirulence · 2026Review
- Morphotype-specific susceptibility toMicrobiology spectrum · 2026Article
- The urgent and challenging superbug fungus Candidozyma auris (formerly Candida auris): a comprehensive review.Antonie van Leeuwenhoek · 2026Review
- Review
- Insights on molecular drivers of phenotypic plasticity in Candidozyma auris.World journal of microbiology & biotechnology · 2026Review
- Article
- Article
- Host-Candida auris interactions in the skin.PLoS pathogens · 2026Review
- Article
- Tackling a global threat: a clinical scenario-based framework for preventing and managingFrontiers in cellular and infection microbiology · 2026Review
- The structural language of fungal cell wall sugars in WHO priority fungi: the determinant of pathogenicity and the gateway to new therapies.Frontiers in immunology · 2026Review
- Xenosiderophore transporter gene expression and clade-specific filamentation in Candida auris killifish (Aphanius dispar) infection.Communications biology · 2025Article
- Article
- Tolerance and heteroresistance to echinocandins inmSphere · 2025Review
- Candida auris cells form giant lipid droplets to survive in harsh environments.Communications biology · 2025Article
- Review
- Relationships BetweenPathogens (Basel, Switzerland) · 2025Article
- Cell aggregation mediated bymSphere · 2024Article
- Application of Raman spectroscopy and machine learning forApplied and environmental microbiology · 2024Article
- Do morphogenetic switching and intraspecies variation enhance virulence of Candida auris?PLoS pathogens · 2024Review
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
Abstract
A striking feature of pathogenic Candida species is morphological plasticity that facilitates environmental adaptation and host infection. Candida auris is an emerging multidrug-resistant fungal pathogen first described in Japan in 2009. In this study, we demonstrate that clinical isolates of C. auris have multiple colony and cellular morphologies including the yeast, filamentous, aggregated, and elongated forms. This phenotypic diversity has been observed in eight clinical isolates of C. auris representing four major genetic clades, suggesting that it could be a general characteristic. We further demonstrate that different cell types of C. auris exhibit distinct antifungal resistance and virulence properties in a Galleria mellonella infection model. Our findings imply that morphological diversity is an important biological feature of C. auris and could be a contributor to its emergence and rapid prevalence worldwide. LAY SUMMARY: Candida auris is an emerging multidrug-resistant fungal pathogen. Morphological analyses indicate that filamentation is a general feature of clinical isolates of C. auris. This ability is associated with antifungal resistance and virulence.
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Registered trials
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