Observational studyArchives of gerontology and geriatrics
Multidimensional prognostic index (MPI) predicts non-invasive ventilation failure in older adults with acute respiratory failure.
Observational study in Archives of gerontology and geriatrics. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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13 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.
- Prevalence of multidimensional frailty and pre-frailty in older people in different settings: A systematic review and meta-analysis.Ageing research reviews · 2021Pooled it
- A comparative evaluation of large language models in aligning with European Respiratory Society (ERS) guidelines for high-flow nasal cannula in acute respiratory failure.Journal of thoracic disease · 2026Article
- Multimodal machine learning predicts type 2 respiratory failure in COPD exacerbations: a multicenter XGBoost model with clinical nomogram.Frontiers in medicine · 2026Article
- Usefulness of a new digital version of the MPI-SVaMA (MPI-SVaMA Digit) in predicting short- and long-term mortality in community-dwelling older people.Aging clinical and experimental research · 2025Article
- Review
- The Multidimensional Prognostic Index predicts incident delirium among hospitalized older patients with COVID-19: a multicenter prospective European study.European geriatric medicine · 2024Article
- The multidimensional prognostic index (MPI) predicts long-term mortality in old type 2 diabetes mellitus patients: a 13-year follow-up study.Journal of endocrinological investigation · 2024Article
- Biomarkers for risk stratification and antibiotic stewardship in elderly patients.Aging clinical and experimental research · 2023Review
- Can the Multidimensional Prognostic Index Improve the Identification of Older Hospitalized Patients with COVID-19 Likely to Benefit from Mechanical Ventilation? An Observational, Prospective, Multicenter Study.Journal of the American Medical Directors Association · 2022Observational
- The challenge of the multifaceted prognosis in the older people and the Multidimensional Prognostic Index.European geriatric medicine · 2021Article
- [Pneumonia in old age].Der Pneumologe · 2021Review
- Multidimensional prognostic index in hospitalized COVID-19 patients with dementia and its relationship with non-invasive ventilation failure.Archives of gerontology and geriatricsArticle
- The multidimensional prognostic index (MPI) for the prognostic stratification of older inpatients with COVID-19: A multicenter prospective observational cohort study.Archives of gerontology and geriatricsObservational
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Authors and funding
15 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAcute respiratory failure (ARF) is a very common complication among hospitalized older adults. Non-invasive ventilation (NIV) may avoid admission to intensive care units, intubation and their related complication, but still lacks specific indications in older adults. Multidimensional Prognostic Index (MPI) based on comprehensive geriatric assessment (CGA) could have a role in defining the short-term prognosis and the best candidates for NIV among older adults with ARF.
methodsThis is a retrospective observational study which enrolled patients older than 70 years, consecutively admitted to an acute geriatric unit with ARF. A standardized CGA was used to calculate the MPI at admission. Multivariate Cox regression models were used to test if MPI score could predict in-hospital mortality and NIV failure. Receiver operator curve (ROC) analysis was used to identify the discriminatory power of MPI for NIV failure.
resultsWe enrolled 231 patients (88.2 ± 5.9 years, 47% females). Mean MPI at admission was 0.76±0.16. In-hospital mortality rate was 33.8%, with similar incidence in patients treated with and without NIV. Among NIV users (26.4%), NIV failure occurred in 39.3%. Higher MPI scores at admission significantly predicted in-hospital mortality (β=4.46, p<0.0001) among patients with ARF and NIV failure (β=7.82, p = 0.001) among NIV users. MPI showed good discriminatory power for NIV failure (area under the curve: 0.72, 95% CI: 0.58-0.85, p<0.001) with optimal cut-off at MPI value of 0.84.
conclusionsMPI at admission might be a useful tool to early detect patients more at risk of in-hospital death and NIV failure among older adults with ARF.
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