Evidence map›Paper›PMID 33484986›Full record

ReviewDiabetes & metabolic syndrome

Potential beneficial role of probiotics on the outcome of COVID-19 patients: An evolving perspective.

Luigi Santacroce, Francesco Inchingolo, Skender Topi, Raffaele Del Prete, Michele Di Cosola, Ioannis Alexandros Charitos, Monica Montagnani

Open access · greenAbstract readReview
In one paragraph

Review in Diabetes & metabolic syndrome. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed, 6 pooled it
6.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 6 syntheses or guidelines pooled it, 86 citations in OpenAlex.

  1. Pooled it
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  6. Pooled it
  7. Trial
  8. Article
  9. Human microbiome in post-acute COVID-19 syndrome (PACS).Current research in microbial sciences · 2025
    Article
  10. Review
  11. Review
  12. Review
  13. Review
  14. Biomolecular Actions by Intestinal Endotoxemia in Metabolic Syndrome.International journal of molecular sciences · 2024
    Review
  15. Review
  16. Current Views About the Link between SARS-CoV-2 and the Liver: Friends or Foe?Endocrine, metabolic & immune disorders drug targets · 2024
    Article
  17. Current View on How Human Gut Microbiota Mediate Metabolic and Pharmacological Activity ofEndocrine, metabolic & immune disorders drug targets · 2024
    Article
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Luigi SantacroceDepartment of Interdisciplinary Medicine, Microbiology and Virology Unit, Medical School, University of Bari "Aldo Moro", Policlinico University Hospital of Bari, p.zza G. Cesare 11, 70124, Bari, Italy; Department of Clinical Disciplines, School of Technical Medical Sciences, "A. Xhuvani" University of Elbasan, Rruga Ismail Zyma, 3001, Elbasan, Albania.
Francesco InchingoloDepartment of Interdisciplinary Medicine, Dentistry Unit, Medical School, University of Bari "Aldo Moro", Policlinico University Hospital of Bari, p.zza G. Cesare 11, 70124, Bari, Italy.
Skender TopiDepartment of Clinical Disciplines, School of Technical Medical Sciences, "A. Xhuvani" University of Elbasan, Rruga Ismail Zyma, 3001, Elbasan, Albania.
Raffaele Del PreteDepartment of Interdisciplinary Medicine, Microbiology and Virology Unit, Medical School, University of Bari "Aldo Moro", Policlinico University Hospital of Bari, p.zza G. Cesare 11, 70124, Bari, Italy.
Michele Di CosolaDepartment of Clinical and Experimental Medicine, Riuniti University Hospital of Foggia, Viale Luigi Pinto 1, 71122, Foggia, Italy.
Ioannis Alexandros CharitosDepartment of Emergency and Urgency, National Poisoning Center, Riuniti University Hospital of Foggia, Viale Luigi Pinto 1, 71122, Foggia, Italy. Electronic address: icharitos@ospedaliriunitifoggia.it.
Monica MontagnaniDepartment of Biomedical Sciences and Human Oncology - Section of Pharmacology, Medical School, University of Bari "Aldo Moro", Policlinico University Hospital of Bari, p.zza G. Cesare 11, 70124, Bari, Italy.
University of Bari Aldo Moro · ITOspedali Riuniti di Foggia · ITUniversity of Elbasan · AL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimsProbiotics can support the body's systems in fighting viral infections. This review is aimed to focus current knowledge about the use of probiotics as adjuvant therapy for COVID-19 patients.

methodsWe performed an extensive research using the PubMed-LitCovid, Cochrane Library, Embase databases, and conducting manual searches on Google Scholar, Elsevier Connect, Web of Science about this issue.

resultsWe have found several papers reporting data about the potential role of probiotics as well as contrasting experimental data about it.

conclusionsMost data show good results demonstrating that probiotics can play a significant role in fighting SARS-CoV-2 infection, also compared with their use in the past for various diseases. They seem effective in lowering inflammatory status, moreover in patients with chronic comorbidities such as cancer and diabetes, improving clinical outcomes.

Indexed as

COVID-19Gastrointestinal MicrobiomeHumansProbioticsTreatment OutcomeDysbiosisHuman microbiotaPharmacological effectsProbioticsSARS-Cov-2

Identifiers

PMID33484986
PMCPMC7804381
OpenAlexW3119959782

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.