ArticleThe Journal of pediatrics2021
Treatment Practices and Outcomes in Continuous Spike and Wave during Slow Wave Sleep: A Multicenter Collaboration.
Article in The Journal of pediatrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
14 citing papers in PubMed, 30 citations in OpenAlex.
- Developmental and/or epileptic encephalopathy with spike-and-wave activation in sleep: Pathophysiological insights and treatment options.Epilepsia · 2026Review
- Developmental and/or Epileptic Encephalopathy with Spike-Wave Activation in Sleep: From Thalamocortical Mechanisms to Precision Therapy.Children (Basel, Switzerland) · 2026Review
- Overreliance on EEG normalization: a case report of DEE-SWAS treated as presumed NCSE leading to avoidable escalation.Frontiers in pediatrics · 2026Article
- Prediction of cognitive impairment in epilepsy with spike-and-wave activation in sleep based on EEG.Therapeutic advances in neurological disorders · 2026Article
- Rebuilding the Tower of Babel: The Current Landscape and Emerging Opportunities in DEE-SWAS.Epilepsy currents · 2025Review
- Efficacy of propofol and midazolam combination in managing refractory epileptic encephalopathy with spike-wave activation in sleep.Epilepsy & behavior reports · 2025Article
- Impact of and research priorities in early onset epilepsy: An investigation of parental concerns.Epilepsy & behavior : E&B · 2024Article
- Interrater reliability of interictal EEG waveforms in Lennox-Gastaut Syndrome.Epilepsia open · 2024Article
- Continuous Spike-Waves during Slow Sleep Today: An Update.Children (Basel, Switzerland) · 2024Review
- Transorbital intraoperative electrocorticography-guided surgical resection for medically refractory developmental epileptic encephalopathy with spike-wave activation in sleep.Epilepsy & behavior reports · 2024Article
- Successful treatment of epileptic encephalopathy with spike wave activation in sleep with anakinra.Epilepsy & behavior reports · 2024Article
- Preliminary evidence of a relationship between sleep spindles and treatment response in epileptic encephalopathy.Annals of clinical and translational neurology · 2023Article
- Preliminary evidence of a relationship between sleep spindles and treatment response in epileptic encephalopathy.bioRxiv : the preprint server for biology · 2023Article
- Is sleep captured during a standard daytime EEG sufficient to diagnose Electrical Status Epilepticus in Sleep.Epilepsy & behavior reports · 2023Article
Corrections and comments
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Authors and funding
14 authors at 11 institutions in 1 country.
Funding
Abstract
objectivesTo determine how continuous spike and wave during slow wave sleep (CSWS) is currently managed and to compare the effectiveness of current treatment strategies using a database from 11 pediatric epilepsy centers in the US. STUDY
designThis retrospective study gathered information on baseline clinical characteristics, CSWS etiology, and treatment(s) in consecutive patients seen between 2014 and 2016 at 11 epilepsy referral centers. Treatments were categorized as benzodiazepines, steroids, other antiseizure medications (ASMs), or other therapies. Two measures of treatment response (clinical improvement as noted by the treating physician; and electroencephalography improvement) were compared across therapies, controlling for baseline variables.
resultsEighty-one children underwent 153 treatment trials during the study period (68 trials of benzodiazepines, 25 of steroids, 45 of ASMs, 14 of other therapies). Children most frequently received benzodiazepines (62%) or ASMs (27%) as first line therapy. Treatment choice did not differ based on baseline clinical variables, nor did these variables correlate with outcome. After adjusting for baseline variables, children had a greater odds of clinical improvement with benzodiazepines (OR 3.32, 95%CI 1.57-7.04, P = .002) or steroids (OR 4.04, 95%CI 1.41-11.59, P = .01) than with ASMs and a greater odds of electroencephalography improvement after steroids (OR 3.36, 95% CI 1.09-10.33, P = .03) than after ASMs.
conclusionsBenzodiazepines and ASMs are the most frequent initial therapy prescribed for CSWS in the US. Our data suggests that ASMs are inferior to benzodiazepines and steroids and support earlier use of these therapies. Multicenter prospective studies that rigorously assess treatment protocols and outcomes are needed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.