ArticleBiological trace element research2021
Cytotoxicity and Genotoxicity of Copper oxide Nanoparticles in chickens.
Article in Biological trace element research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 66 citations in OpenAlex.
- Biological applications and future perspectives of bioactive compounds as pig feed additives.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2026Review
- Evaluation of the antiparasitic efficacy of praziquantel against Prohemistomum vivax (Cyathocotylidae) metacercariae in naturally infected African catfish (Clarias gariepinus).Scientific reports · 2026Article
- Green-synthesized gold nanoparticles: as emerging tools to combat antimicrobial resistance and therapeutic applications in poultry.Veterinary research communications · 2026Review
- In vitro release kinetics of bioactive compounds (gallic acid, ellagic acid, and eugenol) from chitosan polymer and the bioactivity of herb-loaded chitosan-CuO nanocomposites.Scientific reports · 2025Article
- Revolutionizing Veterinary Medicine: The Role of Nanoparticles in Advancing Animal Health, Nutrition and Disease Management.Veterinary medicine and science · 2025Review
- Use of Metallic Nanoparticles Against Eimeria-the Coccidiosis-Causing Agents: A Comprehensive Review.Biological trace element research · 2025Review
- Evaluation of zinc oxide and copper oxide nanoparticles as potential alternatives to antibiotics for managing fowl typhoid in broilers.Journal of animal science and technology · 2024Article
- Mechanistic Approach on the Pulmonary Oxido-Inflammatory Stress Induced by Cobalt Ferrite Nanoparticles in Rats.Biological trace element research · 2024Article
- Chitosan coating silver nanoparticles as a promising feed additive in broilers chicken.BMC veterinary research · 2023Article
- Recent Updates on Multifunctional Nanomaterials as Antipathogens in Humans and Livestock: Classification, Application, Mode of Action, and Challenges.Molecules (Basel, Switzerland) · 2023Review
- Effectiveness of natural biomaterials in the protection and healing of experimentally induced gastric mucosa Ulcer in rats.Molecular biology reports · 2023Article
- Efficacy of zinc oxide and copper oxide nanoparticles on virulence genes of avian pathogenic E. coli (APEC) in broilers.BMC veterinary research · 2023Article
- Metal-based nanomaterials and nanocomposites as promising frontier in cancer chemotherapy.MedComm · 2023Review
- Synthesis, biomedical applications, and toxicity of CuO nanoparticles.Applied microbiology and biotechnology · 2023Review
- Copper Oxide Nanoparticles Exhibit Cell Death Through Oxidative Stress Responses in Human Airway Epithelial Cells: a Mechanistic Study.Biological trace element research · 2022Article
- The effect of metal-containing nanoparticles on the health, performance and production of livestock animals and poultry.The veterinary quarterly · 2022Review
- Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2022Article
- Inorganic Nanoparticles: Toxic Effects, Mechanisms of Cytotoxicity and Phytochemical Interactions.Advanced pharmaceutical bulletin · 2022Review
- Copper-containing nanoparticles: Mechanism of antimicrobial effect and application in dentistry-a narrative review.Frontiers in surgery · 2022Review
- One-Pot Surface Modification of β-CuACS omega · 2021Article
Corrections and comments
- Erratum issued
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Copper oxide nanoparticles (CuO-NPs) are consciously used to control the growth of bacteria, fungi, and algae. Several studies documented the beneficial and hazardous effects of CuO-NPs on human cells and different experimental animals but there are not many studies that report the effect of CuO-NPs in poultry. Therefore, the present study was performed to investigate the dose-dependent effects of copper oxide nanoparticles on the growth performance, immune status, oxidant/antioxidant capacity, DNA status, and histological structures of most edible parts of broiler chickens (muscle, heart, liver, spleen, and kidneys). The experiment was carried out on 90 1-day-old broiler chicks (Cobb 500) which were divided into three experimental groups (n = 30) in three replicates (n = 10). Group 1 was kept as a control group and did not receive copper oxide nanoparticles. Groups 2 and 3 received CuO-NPs by oral gavage at dose 5 mg/kg and 15 mg/kg bwt respectively at 1, 7, 14, 21, 28, and 35 days of the life of the chickens. An increase in the amount of feed intake and weight was recorded every week, and finally, the food conversion ratio (FCR) was calculated. Our results showed dose-dependent increases in malondialdehyde levels, copper contents, DNA fragmentation percent, and microscopic scoring in different examined organs of CuO-NPs-receiving groups associated with a remarkable reduction in weight gain, food conversion ratio, catalase activity, and antibody titer of both New Castle and Avian Influenza viruses. Histopathological alterations were observed in both groups receiving CuO-NPs with some variations in its severity. Our study concluded that CuO-NPs are considered cytotoxic and we recommend not adding them to poultry feed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.