Evidence map›Paper›PMID 33484270›Full record

ArticleCellular and molecular life sciences : CMLS2021

Antimicrobial D-amino acid oxidase-derived peptides specify gut microbiota.

Giulia Murtas, Silvia Sacchi, Gabriella Tedeschi, Elisa Maffioli, Eugenio Notomista, Valeria Cafaro, Monica Abbondi, Jean-Pierre Mothet, Loredano Pollegioni

Open access · hybridAbstract read
In one paragraph

Article in Cellular and molecular life sciences : CMLS, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Review
  6. Review
  7. Excitatory amino acids as therapeutic agents: Reversing neurodegenerative trajectory by tackling excitotoxicity.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
    Review
  8. Review
  9. Article
  10. D-Amino Acids and Cancer: Friends or Foes?International journal of molecular sciences · 2023
    Review
  11. D-Amino Acids as a Biomarker in Schizophrenia.Diseases (Basel, Switzerland) · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Giulia MurtasDepartment of Biotechnology and Life Sciences, University of Insubria, Via J. H. Dunant 3, 21100, Varese, Italy.ORCID http://orcid.org/0000-0002-9086-5520
Silvia SacchiDepartment of Biotechnology and Life Sciences, University of Insubria, Via J. H. Dunant 3, 21100, Varese, Italy.ORCID http://orcid.org/0000-0002-2338-2561
Gabriella TedeschiDepartment of Veterinary Medicine, University of Milan, Milan, Italy.ORCID http://orcid.org/0000-0003-2082-6443
Elisa MaffioliDepartment of Veterinary Medicine, University of Milan, Milan, Italy.ORCID http://orcid.org/0000-0002-5539-1825
Eugenio NotomistaDepartment of Biology, University of Naples Federico II, Naples, Italy.ORCID http://orcid.org/0000-0003-0097-6487
Valeria CafaroDepartment of Biology, University of Naples Federico II, Naples, Italy.ORCID http://orcid.org/0000-0002-6686-7657
Monica AbbondiDAAIR, D-Amino Acid International Research Center, Gerenzano, Italy.ORCID http://orcid.org/0000-0002-8248-2861
Jean-Pierre MothetLuMIn, Université Paris-Saclay, CNRS, ENS Paris-Saclay, CentraleSupélec, 91190, Gif-sur-Yvette, France.ORCID http://orcid.org/0000-0003-4991-0614
Loredano PollegioniDepartment of Biotechnology and Life Sciences, University of Insubria, Via J. H. Dunant 3, 21100, Varese, Italy. loredano.pollegioni@uninsubria.it.ORCID http://orcid.org/0000-0003-1733-7243
University of Insubria · ITUniversity of Milan · ITUniversity of Naples Federico II · ITCentre National de la Recherche Scientifique · FRFondazione Humanitas per la Ricerca · IT

Funding

Fondazione Cariplo Grant 2018-2786
6 · The paper itself

Abstract

The flavoenzyme D-amino acid oxidase (DAAO) is deputed to the degradation of D-enantiomers of amino acids. DAAO plays various relevant physiological roles in different organisms and tissues. Thus, it has been recently suggested that the goblet cells of the mucosal epithelia secrete into the lumen of intestine, a processed and active form of DAAO that uses the intestinal D-amino acids to generate hydrogen peroxide (H

Indexed as

Amino AcidsAmino Acid SequenceAnimalsAnti-Bacterial AgentsD-Amino-Acid OxidaseFemaleGastrointestinal MicrobiomeGram-Negative BacteriaGram-Positive BacteriaHumansIntestine, SmallMaleMiceMice, Inbred C57BLPore Forming Cytotoxic ProteinsProtein ConformationAmino AcidsAnti-Bacterial AgentsD-Amino-Acid OxidasePore Forming Cytotoxic ProteinsD-Amino acidsFlavoproteinMicrobiota selectionNovel function

Identifiers

PMID33484270
PMCPMC8038955
OpenAlexW3123971760

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.