Evidence map›Paper›PMID 33484242›Full record

ArticleGigaScience2021

Lilikoi V2.0: a deep learning-enabled, personalized pathway-based R package for diagnosis and prognosis predictions using metabolomics data.

Xinying Fang, Yu Liu, Zhijie Ren, Yuheng Du, Qianhui Huang, Lana X Garmire

Abstract read
In one paragraph

Article in GigaScience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Xinying FangDepartment of Biostatistics, School of Public Health, University of Michigan, 1415 Washington Heights, Ann Arbor, MI 49109, USA.
Yu LiuDepartment of Computational Medicine and Bioinformatics, University of Michigan, 1600 Huron Parkway, Ann Arbor, MI 48105, USA.
Zhijie RenDepartment of Electric Engineering and Computer Science, 2260 Hayward Street, University of Michigan, Ann Arbor, MI 48109, USA.
Yuheng DuDepartment of Biostatistics, School of Public Health, University of Michigan, 1415 Washington Heights, Ann Arbor, MI 49109, USA.
Qianhui HuangDepartment of Biostatistics, School of Public Health, University of Michigan, 1415 Washington Heights, Ann Arbor, MI 49109, USA.
Lana X GarmireDepartment of Computational Medicine and Bioinformatics, University of Michigan, 1600 Huron Parkway, Ann Arbor, MI 48105, USA.

Funding

An Integrative Omics Approach to Identify Biomarkers Related to Preeclampsia and Breast Cancer RisksR01HD084633 · NICHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GARMIRE, LANA X · 2016 to 2020
$3.0M
Cancer precision medicine through spatially informative single cell image and transcriptomics data analysisR01LM012373 · NLM · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GARMIRE, LANA X · 2016 to 2024
$2.4M
DR. EPS: Drug Repurposing for Extended Patient SurvivalR01LM012907 · NLM · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GARMIRE, LANA X · 2019 to 2022
$1.0M
An Integrative Bioinformatics Approach to Study Single Cancer Cell HeterogeneityK01ES025434 · NIEHS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GARMIRE, LANA X · 2014 to 2018
$905k
NICHD NIH HHS R01 HD084633NIEHS NIH HHS K01 ES025434NLM NIH HHS R01 LM012373NLM NIH HHS R01 LM012907
6 · The paper itself

Abstract

backgroundpreviously we developed Lilikoi, a personalized pathway-based method to classify diseases using metabolomics data. Given the new trends of computation in the metabolomics field, it is important to update Lilikoi software.

resultshere we report the next version of Lilikoi as a significant upgrade. The new Lilikoi v2.0 R package has implemented a deep learning method for classification, in addition to popular machine learning methods. It also has several new modules, including the most significant addition of prognosis prediction, implemented by Cox-proportional hazards model and the deep learning-based Cox-nnet model. Additionally, Lilikoi v2.0 supports data preprocessing, exploratory analysis, pathway visualization, and metabolite pathway regression. CONCULSION: Lilikoi v2.0 is a modern, comprehensive package to enable metabolomics analysis in R programming environment.

Indexed as

Deep LearningMachine LearningMetabolomicsProportional Hazards ModelsSoftwareclassificationdeep learningmetabolomicsneural networkpathwayprognosissurvival analysisvisualization

Identifiers

PMID33484242
PMCPMC7825009

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.