Evidence map›Paper›PMID 33484216›Full record

ArticleJournal of cardiovascular electrophysiology2021

Feasibility of intraprocedural integration of cardiac CT to guide left ventricular lead implantation for CRT upgrades.

Justin Gould, Baldeep S Sidhu, Benjamin J Sieniewicz, Bradley Porter, Angela W C Lee, Orod Razeghi, Jonathan M Behar, Vishal Mehta, Mark K Elliott, Daniel Toth and 5 more

Open access · hybridAbstract read
In one paragraph

Article in Journal of cardiovascular electrophysiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Upgrading right ventricular pacemakers to biventricular pacing or conduction system pacing: a systematic review and meta-analysis.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2023
    Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 2 countries.

Justin GouldDepartment of Cardiology, Guy's and St Thomas' NHS Foundation Trust, London, UK.ORCID 0000-0002-1897-5565
Baldeep S SidhuDepartment of Cardiology, Guy's and St Thomas' NHS Foundation Trust, London, UK.ORCID 0000-0002-1999-7360
Benjamin J SieniewiczDepartment of Cardiology, Guy's and St Thomas' NHS Foundation Trust, London, UK.ORCID 0000-0002-9655-7465
Bradley PorterDepartment of Cardiology, Guy's and St Thomas' NHS Foundation Trust, London, UK.
Angela W C LeeSchool of Biomedical Engineering and Imaging Sciences, King's College, London, UK.
Orod RazeghiSchool of Biomedical Engineering and Imaging Sciences, King's College, London, UK.ORCID 0000-0003-4989-5565
Jonathan M BeharDepartment of Cardiology, Guy's and St Thomas' NHS Foundation Trust, London, UK.
Vishal MehtaDepartment of Cardiology, Guy's and St Thomas' NHS Foundation Trust, London, UK.
Mark K ElliottDepartment of Cardiology, Guy's and St Thomas' NHS Foundation Trust, London, UK.ORCID 0000-0003-2805-3043
Daniel TothSchool of Biomedical Engineering and Imaging Sciences, King's College, London, UK.
Ulrike HaberlandMedical Imaging Technologies, Siemens Healthineers, Malvern, Pennsylvania, USA.
Reza RazaviDepartment of Cardiology, Guy's and St Thomas' NHS Foundation Trust, London, UK.
Ronak RajaniDepartment of Cardiology, Guy's and St Thomas' NHS Foundation Trust, London, UK.
Steven NiedererSchool of Biomedical Engineering and Imaging Sciences, King's College, London, UK.
Christopher A RinaldiDepartment of Cardiology, Guy's and St Thomas' NHS Foundation Trust, London, UK.
King's College London · GBSiemens Healthcare (United States) · US

Funding

British Heart Foundation PG/15/91/31812Wellcome TrustWellcome Trust WT203148/Z/16/Z
6 · The paper itself

Abstract

backgroundOptimal positioning of the left ventricular (LV) lead is an important determinant of cardiac resynchronization therapy (CRT) response.

objectiveEvaluate the feasibility of intraprocedural integration of cardiac computed tomography (CT) to guide LV lead implantation for CRT upgrades.

methodsPatients undergoing LV lead upgrade underwent ECG-gated cardiac CT dyssynchrony and LV scar assessment. Target American Heart Association segment selection was determined using latest non-scarred mechanically activating segments overlaid onto real-time fluoroscopy with image co-registration to guide optimal LV lead implantation. Hemodynamic validation was performed using a pressure wire in the LV cavity (dP/dt

results18 patients (male 94%, 55.6% ischemic cardiomyopathy) with RV pacing burden 60.0 ± 43.7% and mean QRS duration 154 ± 30 ms underwent cardiac CT. 10/10 ischemic patients had CT evidence of scar and these segments were excluded as targets. Seventeen out of 18 (94%) patients underwent successful LV lead implantation with delivery to the CT target segment in 15 out of 18 (83%) of patients. Acute hemodynamic response (dP/dt

conclusionIntraprocedural integration of cardiac CT to guide optimal LV lead placement is feasible with superior hemodynamics when pacing in CT target segments and favorable volumetric response rates, despite a high proportion of patients with ischemic cardiomyopathy. Multicentre, randomized controlled studies are needed to evaluate whether intraprocedural integration of cardiac CT is superior to standard care.

Indexed as

Cardiac Resynchronization TherapyHeart FailureFeasibility StudiesHeart VentriclesHumansMaleTomographyTomography, X-Ray ComputedTreatment Outcomecardiac CTCRTimage guidanceimproving CRT response

Identifiers

PMID33484216
PMCPMC8647921
OpenAlexW3124713705

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.