ArticleActa diabetologica2021
Coeliac disease is associated with depression in children and young adults with type 1 diabetes: results from a multicentre diabetes registry.
Article in Acta diabetologica, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 13 citations in OpenAlex.
- Moderating effect for illness uncertainty on the relationship of depressive and anxiety symptoms among patients with type 1 diabetes in Taif region, Saudi Arabia.Journal of family medicine and primary care · 2024Article
- Maintaining a gluten-free diet is associated with quality of life in youths with type 1 diabetes and celiac disease.Acta diabetologica · 2024Article
- Outpatient screening for anxiety and depression symptoms in adolescents with type 1 diabetes - a cross-sectional survey.Child and adolescent psychiatry and mental health · 2023Article
- Early vs late histological confirmation of coeliac disease in children with new-onset type 1 diabetes.Diabetologia · 2022Article
- Review
- Celiac disease in the COVID-19 pandemic.Journal of translational autoimmunity · 2021Article
- Impact of pediatric gastrointestinal disorders on learning and cognitive development in schoolchildren.Annals of gastroenterologyReview
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Authors and funding
9 authors at 5 institutions in 2 countries.
Funding
Abstract
aimsTo analyse the association between coeliac disease (CD) and depression in children, adolescents, and young adults with type 1 diabetes (T1D).
methodsWe included 79,067 T1D patients aged 6-20 years, with at least six months of diabetes duration, and treatment data between 1995 and 2019 were documented in the diabetes patient follow-up registry. We categorized patients into four groups: T1D only (n = 73,699), T1 + CD (n = 3379), T1D + depression (n = 1877), or T1D + CD + depression (n = 112).
resultsCD and depression were significantly associated (adjusted OR: 1.25 [1.03-1.53]). Females were more frequent in both the depression and the CD group compared with the T1D only group. Insulin pumps were used more frequently in T1D + CD and T1D + depression compared with T1D only (both p < .001). HbA1c was higher in T1D + depression (9.0% [8.9-9.0]), T1D + CD + depression (8.9% [8.6-9.2]), both compared with T1D only (8.2% [8.2-8.2], all p < .001). We found comorbid autism, attention deficit hyperactivity disorder, anxiety, schizophrenia, and eating disorders more frequently in the T1D + CD + depression group compared with T1D only (all p < .001).
conclusionsCD and depression are associated in young T1D patients. The double load of T1D and CD may lead to an increased risk for depression. Depression was associated with additional psychological and neurological comorbidities. Aside from imperative CD screening after T1D diagnosis and regular intervals, depression screening might be helpful in routine care, especially in patients with diagnosed CD.
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