ArticleMolecular psychiatry2021
Polygenic risk for autism, attention-deficit hyperactivity disorder, schizophrenia, major depressive disorder, and neuroticism is associated with the experience of childhood abuse.
Article in Molecular psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 3 of them syntheses that pooled it.
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Who cites it
31 citing papers in PubMed, 3 syntheses or guidelines pooled it, 45 citations in OpenAlex.
- Genetic and environment influences on childhood victimization: a systematic review and meta-analysis.Molecular psychiatry · 2025Pooled it
- Childhood Maltreatment and Mental Health Problems: A Systematic Review and Meta-Analysis of Quasi-Experimental Studies.The American journal of psychiatry · 2023Pooled it
- Schizophrenia Polygenic Risk and Experiences of Childhood Adversity: A Systematic Review and Meta-analysis.Schizophrenia bulletin · 2022Pooled it
- The Transdiagnostic Association Between Childhood Trauma and Accelerated Brain Aging in Two Independent Datasets.Schizophrenia bulletin · 2026Article
- Violent and sexual victimisation and incident anxiety, mood and substance use disorders in childhood and adolescence: a co-sibling study.Journal of child psychology and psychiatry, and allied disciplines · 2026Article
- Association between GRIK1 rs363598 and intergenic rs360932 variants and susceptibility to autism spectrum disorders in Egyptian children.BMC pediatrics · 2025Article
- Systematic Review and Meta-Analysis: Phenotypic Correlates of the Autism Polygenic Score.JAACAP open · 2025Article
- Childhood trauma and subclinical cin early adulthood: A genetically informative study.European psychiatry : the journal of the Association of European Psychiatrists · 2025Article
- Genetic Evidence Supporting a Role for Brain Region Volume and Functional Network Alterations in Major Depression.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Autistic traits in childhood and post-traumatic stress disorder as young adults: a cohort study.Journal of child psychology and psychiatry, and allied disciplines · 2025Article
- Shared Genetic Architecture Among Severe Mental Disorders: A System Biology Approach Based on Protein-Protein Interaction.Brain and behavior · 2025Article
- Polygenic risk scores for severe psychiatric disorders in bipolar disorders: associations with the clinical and dimensional expression, interactions with childhood maltreatment and mediation models.Translational psychiatry · 2025Article
- The Many Faces of Child Abuse: How Clinical, Genetic and Epigenetic Correlates Help Us See the Full Picture.Children (Basel, Switzerland) · 2025Review
- Categorical misalignment: Making autism(s) in big data biobanking.Social studies of science · 2025Article
- Associations between childhood maltreatment and personality traits in individuals with and without depression: a CTQ-based assessment.BMC psychology · 2025Article
- Research Review: Why do prospective and retrospective measures of maltreatment differ? A narrative review.Journal of child psychology and psychiatry, and allied disciplines · 2024Review
- Patterns of stressful life events and polygenic scores for five mental disorders and neuroticism among adults with depression.Molecular psychiatry · 2024Article
- Childhood maltreatment and health in the UK Biobank: triangulation of outcome-wide and polygenic risk score analyses.BMC medicine · 2024Article
- Polygenic risk for major depression, attention deficit hyperactivity disorder, neuroticism, and schizophrenia are correlated with experience of intimate partner violence.Translational psychiatry · 2024Article
- Positive parent-child interactions moderate certain maltreatment effects on psychosocial well-being in 6-year-old children.Pediatric research · 2024Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
People who experience childhood abuse are at increased risk of mental illness. Twin studies suggest that inherited genetic risk for mental illness may account for some of these associations. Yet, the hypothesis that individuals who have experienced childhood abuse may carry genetic loading for mental illness has never been tested with genetic data. Using polygenic risk scores for six psychiatric disorders-attention-deficit hyperactivity disorder (ADHD), autism spectrum disorder (ASD), bipolar disorder (BPD), major depressive disorder (MDD), neuroticism, and schizophrenia-we tested whether genetic risk for mental illness was associated with increased risk of experiencing three types of childhood abuse: physical/emotional abuse, physical assault, and sexual abuse, in a cohort of white non-Hispanic women (n = 11,315). ADHD and MDD genetic risk scores were associated with a higher risk of experiencing each type of childhood abuse, while neuroticism, schizophrenia, BPD, and ASD genetic scores were associated with a higher risk of experiencing physical/emotional abuse and physical assault, but not sexual abuse. Sensitivity analyses examining potential bias from the differential recall of childhood trauma, parental socioeconomic status, and population stratification were consistent with the main findings. A one-standard-deviation increase in genetic risk for mental illness was associated with a modestly elevated risk of experiencing childhood abuse (OR range: 1.05-1.19). Therefore, inherited genetic risk may partly account for the association of childhood abuse with mental illness. In addition, future treatments for mental illness will benefit from taking into consideration the co-occurrence of childhood trauma and genetic loading.
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