Evidence map›Paper›PMID 3348362›Full record

ArticleThe American journal of pathology1988

Effect of cell substrate on antioxidant enzyme activities in cultured renal glomerular epithelium.

A H Yang, T D Oberley, L W Oberley, R Ramanathan

Abstract read
In one paragraph

Article in The American journal of pathology, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Immunogold analysis of antioxidant enzymes in human renal cell carcinoma.Virchows Archiv : an international journal of pathology · 1994
    Article
  4. Effect of fibrin matrix on growth of glomerular cells.The American journal of pathology · 1992
    Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

A H YangDepartment of Pathology, University of Wisconsin School of Medicine, Madison.
T D Oberley
L W Oberley
R Ramanathan

Funding

SUPEROXIDE DISMUTASE LEVELS IN TUMOR CELLSR01CA041267 · NCI · UNIVERSITY OF IOWA · PI OBERLEY, LARRY · 1986 to 1995
–
NCI NIH HHS 1-R01-CA41267
6 · The paper itself

Abstract

The activities of three antioxidant enzymes, superoxide dismutase, catalase, and glutathione peroxidase, were monitored in isolated guinea pig glomeruli and primary or subcultured glomerular epithelial cells. Cell injury was assessed by morphologic studies and by measurement of cellular lipid peroxidation (levels of malondialdehyde). Antioxidant enzyme activities were very different in cultured cells than in parent glomeruli. The possible effect of culture substrates (tissue culture plastic, bovine corneal endothelial [BCE] cell basement membrane, and PF-HR-9 endodermal cell basement membrane) on antioxidant enzyme status, cell morphology, and lipid peroxidation was also assessed. Glomerular epithelial cells cultured on the BCE cell basement membrane substrate survived longer and showed less lipid peroxidation than cells cultured on plastic or the HR-9 substrate. Cells cultured on a plastic substrate had substantially less glutathione peroxidase activity than cells cultured on either BCE or HR-9 basement membranes.

Indexed as

AnimalsAntioxidantsCatalaseCells, CulturedCulture MediaEpitheliumGlutathione PeroxidaseGuinea PigsKidney GlomerulusLipid PeroxidesMicroscopy, ElectronSuperoxide DismutaseAntioxidantsCatalaseCulture MediaGlutathione PeroxidaseLipid PeroxidesSuperoxide Dismutase

Identifiers

PMID3348362
PMCPMC1880660

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.