ArticleScientific reports2021
Understanding the interactions of poly(methyl methacrylate) and poly(vinyl chloride) nanoparticles with BHK-21 cell line.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 80 citations in OpenAlex.
- Effects of Aged Polymethylmethacrylate Microplastics on Physiological Biochemistry and Intestinal-Sediment Microbial Communities ofAnimals : an open access journal from MDPI · 2026Article
- Toxicokinetics and Toxicodynamics of Nanoplastics inEnvironment & health (Washington, D.C.) · 2026Article
- Carboxyl Surface Modification Attenuates Polystyrene- but Not Poly(methyl methacrylate) Nanoplastic-Induced Gut Dysbiosis in Zebrafish Larvae.Environment & health (Washington, D.C.) · 2026Article
- Development of Curcumin-Loaded Hybrid Lipid-Polymeric Nanoparticles for Hypoxia-Related Applications.International journal of nanomedicine · 2026Article
- Fluorescent nanoplastics: What steps are needed towards a representative toolkit?Microplastics and nanoplastics · 2026Review
- Polymethyl methacrylate microplastics affect oral microbiota diversity andFrontiers in microbiology · 2026Article
- Aromatic Polymethacrylates from Lignin-Based Feedstock: Synthesis, Thermal Properties, Life-Cycle Assessment and Toxicity.ChemSusChem · 2025Article
- Advances in Parenteral Nanocarriers and Delivery Devices: A Comprehensive Review.Current pharmaceutical design · 2025Review
- Overcoming Resistance of Caco-2 Cells to 5-Fluorouracil through Diruthenium Complex Encapsulation in PMMA Nanoparticles.Inorganic chemistry · 2024Article
- Multi-Omics Analysis Reveals the Toxicity of Polyvinyl Chloride Microplastics toward BEAS-2B Cells.Toxics · 2024Article
- Interfacial Interactions between Nanoplastics and Biological Systems: toward an Atomic and Molecular Understanding of Plastics-Driven Biological Dyshomeostasis.ACS applied materials & interfaces · 2024Article
- Polystyrene microplastics exposition on human placental explants induces time-dependent cytotoxicity, oxidative stress and metabolic alterations.Frontiers in endocrinology · 2024Article
- Characterization of Nanoprecipitated PET Nanoplastics byPolymers · 2023Article
- New PMMA-Based Hydroxyapatite/ZnFeBiomimetics (Basel, Switzerland) · 2023Article
- SGLT2 inhibition ameliorates nano plastics-induced premature endothelial senescence and dysfunction.Scientific reports · 2023Article
- Novel Injectable Fluorescent Polymeric Nanocarriers for Intervertebral Disc Application.Journal of functional biomaterials · 2023Article
- Fabrication of Nylon-6 and Nylon-11 Nanoplastics and Evaluation in Mammalian Cells.Nanomaterials (Basel, Switzerland) · 2022Article
- Bioanalytical approaches for the detection, characterization, and risk assessment of micro/nanoplastics in agriculture and food systems.Analytical and bioanalytical chemistry · 2022Review
- Cytotoxicity of Methacrylate Dental Resins to Human Gingival Fibroblasts.Journal of functional biomaterials · 2022Article
- A Cell Culture Chip with Transparent, Micropillar-Decorated Bottom for Live Cell Imaging and Screening of Breast Cancer Cells.Micromachines · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Microplastic and nanoplastic particles are prevalent in the environment and are beginning to enter the living system through multiple channels. Currently, little is known about the impact of plastic nanoparticles in living organisms. In order to investigate the health impact of micro- and nanoparticles of common polymers in a systematic way, luminescent plastic nanoparticles from two common polymers, polyvinyl chloride (PVC) and poly (methyl methacrylate) (PMMA) with relatively narrow size distribution are prepared using a nanoprecipitation method. As a model system, BHK-21 cells were exposed to polymer nanoparticles to understand the mode of uptake, internalization and biochemical changes inside the cells. The cellular effects of the nanoparticles were evaluated by monitoring the changes in cell viability, cell morphology, concentrations of reactive oxygen species (ROS), adenine triphosphate (ATP) and lactate dehydrogenase at different concentrations of the nanoparticles and time of exposure. PVC and PMMA nanoparticles induced a reduction in the cell viability along with a reduction of ATP and increase of ROS concentrations in a dose- and time-dependent manner. The plastic nanoparticles are internalized into the cell via endocytosis, as confirmed by Dynasore inhibition assay and colocalization with latex beads. Our findings suggest that plastic nanoparticle internalization could perturb cellular physiology and affect cell survival under laboratory conditions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.