ArticleCommunications biology2021
Artificial hibernation/life-protective state induced by thiazoline-related innate fear odors.
Article in Communications biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 26 citations in OpenAlex.
- Limb restraint induces a rapid and profound decrease in core body temperature associated with the stress response in mice.PNAS nexus · 2026Article
- Hydrogen sulfide as a potent predator-derived kairomone mediating fear-related responses in mice.Communications biology · 2025Article
- Metabolomics-Guided Genomic Comparisons Reveal Convergent Evolution of Hibernation Genes in Mammals.Molecular biology and evolution · 2025Article
- Perinatal SSRI exposure impacts innate fear circuit activation and behavior in mice and humans.Nature communications · 2025Article
- Mechanosensation of the heart and gut elicits hypometabolism and vigilance in mice.Nature metabolism · 2025Article
- Sex Differences in the Neuroendocrine Stress Response: A View from a CRH-Reporting Mouse Line.International journal of molecular sciences · 2024Article
- A molecularly defined amygdala-independent tetra-synaptic forebrain-to-hindbrain pathway for odor-driven innate fear and anxiety.Nature neuroscience · 2024Article
- Advances in neural circuits of innate fear defense behavior.Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2023Review
- Recruitment of Corticotropin-Releasing Hormone (CRH) Neurons in Categorically Distinct Stress Reactions in the Mouse Brain.International journal of molecular sciences · 2023Article
- Article
- Transient Receptor Potential Ankyrin-1-expressing vagus nerve fibers mediate IL-1β induced hypothermia and reflex anti-inflammatory responses.Molecular medicine (Cambridge, Mass.) · 2023Article
- Avoidance of thiazoline compound depends on multiple sensory pathways mediated by TrpA1 and ORs inFrontiers in molecular neuroscience · 2023Article
- Detection of neuronal defensive discharge information transmission and characteristics in periaqueductal gray double-subregions using PtNP/PEDOT:PSS modified microelectrode arrays.Microsystems & nanoengineering · 2023Article
- Machine learning-based clustering and classification of mouse behaviors via respiratory patterns.iScience · 2022Article
- The Endocannabinoid 2-Arachidonoylglycerol Bidirectionally Modulates Acute and Protracted Effects of Predator Odor Exposure.Biological psychiatry · 2022Article
- Energy-sparing by 2-methyl-2-thiazoline protects heart from ischaemia/reperfusion injury.ESC heart failure · 2022Article
- Posterior subthalamic nucleus (PSTh) mediates innate fear-associated hypothermia in mice.Nature communications · 2021Article
- Thiazoline-related innate fear stimuli orchestrate hypothermia and anti-hypoxia via sensory TRPA1 activation.Nature communications · 2021Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Innate fear intimately connects to the life preservation in crises, although this relationships is not fully understood. Here, we report that presentation of a supernormal innate fear inducer 2-methyl-2-thiazoline (2MT), but not learned fear stimuli, induced robust systemic hypothermia/hypometabolism and suppressed aerobic metabolism via phosphorylation of pyruvate dehydrogenase, thereby enabling long-term survival in a lethal hypoxic environment. These responses exerted potent therapeutic effects in cutaneous and cerebral ischemia/reperfusion injury models. In contrast to hibernation, 2MT stimulation accelerated glucose uptake in the brain and suppressed oxygen saturation in the blood. Whole-brain mapping and chemogenetic activation revealed that the sensory representation of 2MT orchestrates physiological responses via brain stem Sp5/NST to midbrain PBN pathway. 2MT, as a supernormal stimulus of innate fear, induced exaggerated, latent life-protective effects in mice. If this system is preserved in humans, it may be utilized to give rise to a new field: "sensory medicine."
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.