Mild synthesis of isoxazoline derivatives via an efficient [4 + 1] annulation reaction of transient nitrosoalkenes and sulfur ylides.

Ting-Bi Hua, Cheng-Xiong Liu, Wei-Min Hu, Long Wang, Qing-Qing Yang

Abstract read

In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Ting-Bi Hua *Key Laboratory of Inorganic Nonmetallic Crystalline and Energy Conversion Materials, College of Materials and Chemical Engineering, China Three Gorges University, Yichang, 443002, Hubei, China.

Cheng-Xiong Liu *Hubei Key Laboratory of Natural Products Research and Development, China Three Gorges University, 8 Daxue Road, Yichang, 443002, Hubei, China.

Wei-Min HuKey Laboratory of Inorganic Nonmetallic Crystalline and Energy Conversion Materials, College of Materials and Chemical Engineering, China Three Gorges University, Yichang, 443002, Hubei, China.

Long WangKey Laboratory of Inorganic Nonmetallic Crystalline and Energy Conversion Materials, College of Materials and Chemical Engineering, China Three Gorges University, Yichang, 443002, Hubei, China. wanglongchem@ctgu.edu.cn.

Qing-Qing YangKey Laboratory of Inorganic Nonmetallic Crystalline and Energy Conversion Materials, College of Materials and Chemical Engineering, China Three Gorges University, Yichang, 443002, Hubei, China. qingqing_yang@ctgu.edu.cn.

Funding

National Natural Science Foundation of China No. 21702121Open fund from Hubei Key Laboratory of Natural Products Research and Development of China Three Gorges University No. NPRD-2018010the 111 project D20015

6 · The paper itself

Abstract

An efficient [4 + 1] annulation between α-bromooximes and sulfur ylides via in situ generation of nitrosoalkenes under mild basic reaction conditions has been developed, providing an expeditious and scalable approach to synthesize biologically interesting isoxazoline derivatives with good to excellent yields.

Identifiers

PMID33483530

DOI10.1038/s41598-021-81370-w

PMCPMC7822858

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