Observational studyScientific reports2021
Perceptual insensitivity to the modulation of interoceptive signals in depression, anxiety, and substance use disorders.
Observational study in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06332963 (Interoceptive Mechanisms of Body Image Disturbance in Anorexia Nervosa), which is not on this map. Cited by 43 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Interoceptive Mechanisms of Body Image Disturbance in Anorexia Nervosa
Who cites it
43 citing papers in PubMed.
- Mindfulness Training vs Recovery Support for Opioid Use, Craving, and Anxiety During Buprenorphine Treatment: A Randomized Clinical Trial.JAMA network open · 2025Trial
- Change starts with the body: Interoceptive appreciation mediates the effect of mindfulness training on behavior change - an effect moderated by depression severity.Psychiatry research · 2024Trial
- Computational mechanisms of learning and forgetting differentiate affective and substance use disorders.Molecular psychiatry · 2026Article
- Evidence for Cardiac Phase-Linked Perception of Heartbeats.Psychophysiology · 2026Article
- The cognitive and motor determinants of the perception of effort.Cognitive, affective & behavioral neuroscience · 2026Article
- Validity and Reliability of the Heart Rate Matching Task: A Novel Measure of Heart Rate Estimation.Psychophysiology · 2026Article
- Intraindividual Variability Matters for the Correspondence Between Subjective Arousal, Valence, and Physiological Responses.Psychophysiology · 2026Article
- Bridging interoception and time perspective: toward an embodied model of consciousness.Frontiers in psychology · 2026Article
- The relationship between interoception of breathing, anxiety, and resting-state functional connectivity in the brain.Cognitive, affective & behavioral neuroscience · 2025Article
- Interoceptive Accuracy, Sensitivity, and Attention are Associated with Suicidal Thoughts and Behaviors.Behavior therapy · 2025Article
- Microstructural Brain Correlates of Inter-individual Differences in Respiratory Interoception.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Factors Linking Interoception and Sleep Across the Adult Lifespan.Psychophysiology · 2025Article
- Inconsistent Bodily Feedback? Interoceptive Sensibility Affects Internet Gaming Disorder in Emerging Adults.Behavioral sciences (Basel, Switzerland) · 2025Article
- Neurophysiological dynamics of visceral signals in emotion, self and bodily consciousness.Proceedings. Biological sciences · 2025Review
- Measuring Cardiac Interoceptive Accuracy in Infancy: Lessons From the Adult Literature.Psychophysiology · 2025Review
- A Computational Account of the Development and Evolution of Psychotic Symptoms.Biological psychiatry · 2025Review
- Computational Mechanisms of Approach-Avoidance Conflict Predictively Differentiate Between Affective and Substance Use Disorders.Computational psychiatry (Cambridge, Mass.) · 2025Article
- Interoceptive Processing in Substance Use Disorders (SUDs): From the Neuroanatomy to Insights from Computational Models and Predictive Coding Frameworks.Current topics in behavioral neurosciences · 2025Review
- Modality-specific effects of threat on self-motion perception.BMC biology · 2024Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
This study employed a series of heartbeat perception tasks to assess the hypothesis that cardiac interoceptive processing in individuals with depression/anxiety (N = 221), and substance use disorders (N = 136) is less flexible than that of healthy individuals (N = 53) in the context of physiological perturbation. Cardiac interoception was assessed via heartbeat tapping when: (1) guessing was allowed; (2) guessing was not allowed; and (3) experiencing an interoceptive perturbation (inspiratory breath hold) expected to amplify cardiac sensation. Healthy participants showed performance improvements across the three conditions, whereas those with depression/anxiety and/or substance use disorder showed minimal improvement. Machine learning analyses suggested that individual differences in these improvements were negatively related to anxiety sensitivity, but explained relatively little variance in performance. These results reveal a perceptual insensitivity to the modulation of interoceptive signals that was evident across several common psychiatric disorders, suggesting that interoceptive deficits in the realm of psychopathology manifest most prominently during states of homeostatic perturbation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.