ArticleNature communications2021
Halo-fluorescein for photodynamic bacteria inactivation in extremely acidic conditions.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 60 citations in OpenAlex.
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- Acid-Tolerant Photosensitizer: Photodynamic Inactivation of Porphyromonas gingivalis by 2',4',5',7'-Tetraiodofluorescein.Pathogens (Basel, Switzerland) · 2026Article
- Absorption Patterns of Fucoidan Oligosaccharides fromFoods (Basel, Switzerland) · 2025Article
- Nanozymes for Treating Ocular Diseases.Advanced healthcare materials · 2025Review
- Identification and validation of reference genes for quantitative gene expression analysis under 409 and 415 nm antimicrobial blue light treatment.Frontiers in molecular biosciences · 2024Article
- Adoptive macrophage directed photodynamic therapy of multidrug-resistant bacterial infection.Nature communications · 2023Article
- An acidic medium-compatible deep-near-infrared dye for in vivo imaging.Smart molecules : open access · 2023Article
- THQ-Xanthene: An Emerging Strategy to Create Next-Generation NIR-I/II Fluorophores.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Review
- A Rational Design of Metal-Organic Framework Nanozyme with High-Performance Copper Active Centers for Alleviating Chemical Corneal Burns.Nano-micro letters · 2023Article
- COVID-19-inspired "artificial virus" to combat drug-resistant bacteria by membrane-intercalation- photothermal-photodynamic multistage effects.Chemical engineering journal (Lausanne, Switzerland : 1996) · 2022Article
- Multicolor ultralong phosphorescence from perovskite-like octahedral α-AlFNature communications · 2022Article
- Antibacterial Activity of the Essential Oil FromFrontiers in microbiology · 2022Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aciduric bacteria that can survive in extremely acidic conditions (pH < 4.0) are challenging to the current antimicrobial approaches, including antibiotics and photodynamic bacteria inactivation (PDI). Here, we communicate a photosensitizer design concept of halogenation of fluorescein for extremely acidic PDI. Upon halogenation, the well-known spirocyclization that controls the absorption of fluorescein shifts to the acidic pH range. Meanwhile, the heavy atom effect of halogens boosts the generation of singlet oxygen. Accordingly, several photosensitizers that could work at even pH < 2.0 were discovered for a broad band of aciduric bacteria families, with half maximal inhibitory concentrations (IC
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.